Genetic and Functional Evaluation of the Role of FOXO1 in Antituberculosis Drug-Induced Hepatotoxicity

Table 1

The distributions of genotype and allele frequencies of all the selected SNPs.

Gene	dbSNP	Variant	Allele				Genotype
			ATDH	Non-ATDH	OR (95% CI)		ATDH	Non-ATDH
			1/2	1/2			11/12/22	11/12/22
ALAS1	rs353556	A > G	116/120	583/673	1.067 (0.683–1.666)	0.775	29/58/31	128/327/173	0.590
	rs3852071	C > T	30/204	210/1042	0.733 (0.466–1.154)	0.180	1/28/88	16/178/432	0.285
	rs352169	G > A	90/144	448/806	1.130 (0.752–1.697)	0.556	17/56/44	75/298/254	0.692
FOXO1	rs2755237	A > C	99/137	527/729	0.631 (0.423–0.942)	0.024	4/45/68	40/293/292	0.059
	rs2701891	T > C	53/181	373/877	1.176 (0.793–1.744)	0.418	13/44/61	42/236/350	0.244
	rs3751436	T > C	70/166	320/936	1.181 (0.775–1.798)	0.437	18/60/38	84/314/229	0.684
	rs4435111	C > T	96/136	482/772	0.572 (0.372–0.879)	0.010	2/32/83	29/233/366	0.026
	rs7325594	T > C	8/228	46/1210	1.432 (0.924–2.219)	0.107	18/68/32	82/327/218	0.266

: the value was calculated using a logistic regression method. “1” = mutant allele; “2” = wild-type allele; “11” = mutant homozygote; “12” = heterozygote; “22” = wild-type homozygote.