Evidence-Based Complementary and Alternative Medicine / 2021 / Article / Tab 2 / Research Article
Combined Metabolomics and Network Toxicology to Explore the Molecular Mechanism of Phytolacca acinose Roxb-Induced Hepatotoxicity in Zebrafish Larvae in Vivo Table 2 35 metabolites contributing to the separation between the control and treated groups exposed to PAR (
< 0.05).
Class Metabolites Formula HMDBID KEGGID VIP P -valueFC Corr.Coeffs. Effect Amino acid Urea CH4 N2 O HMDB00294 C00086 2.2 6.49E − 04 0.6 −0.84 Amino acid Ornithine C5 H12 N2 O2 HMDB00214 C00077 2.2 7.21E − 05 0.7 −0.84 Amino acid L-Tryptophan C11 H12 N2 O2 HMDB00929 C00078 2.2 3.08E − 04 0.8 −0.84 Amino acid L-Methionine C5 H11 NO2 S HMDB00696 C00073 2.2 1.56E − 04 0.8 −0.83 Amino acid L-norleucine C6 H13 NO2 HMDB01645 C01933 2.2 2.95E − 04 0.7 −0.82 Carbohydrates D-Xylose C5 H10 O5 HMDB00098 C00181 2.1 7.02E − 04 0.6 −0.79 Nucleotide Isoxanthopterin C6 H5 N5 O2 HMDB00704 C03975 2.0 1.25E − 03 1.7 0.74 Amino acid Ratio of putrescine/ornithine C4 H12 N2 /C5 H12 N2 O2 HMDB01414/HMDB00214 C00134/C00077 2.0 1.71E − 03 1.1 0.74 Organic acids L-Pipecolic acid C6 H11 NO2 HMDB00716 C00408 1.9 2.52E − 03 2.5 0.73 Amino acid L-Alpha-aminobutyric acid C4 H9 NO2 HMDB00452 C02356 1.8 4.70E − 03 0.8 −0.69 Amino acid L-Cystine C6 H12 N2 O4 S2 HMDB00192 C00491 1.8 3.92E − 03 0.7 −0.68 Amino acid L-Threonine C4 H9 NO3 HMDB00167 C00188 1.8 8.37E − 03 0.8 −0.68 Nucleotide Hypoxanthine C5 H4 N4 O HMDB00157 C00262 1.8 5.34E − 03 0.9 −0.67 Amino acid L-Cysteine C3 H7 NO2 S HMDB00574 C00097 1.8 1.10E − 02 0.8 −0.66 Organic acids 2-Hydroxy-3-methylbutyric acid C5 H10 O3 HMDB00407 NA 1.8 7.05E − 03 0.8 −0.66 Amino acid 2-Aminoadipate C6 H11 NO4 HMDB00510 C00956 1.7 8.61E − 03 0.8 −0.65 Nucleotide Ratio of hypoxanthine/inosinic acid C5 H4 N4 O/C10 H13 N4 O8 P HMDB00157/HMDB00175 C00262/C00130 1.7 5.96E − 03 0.7 −0.65 Amino acid L-Asparagine C4 H8 N2 O3 HMDB00168 C00152 1.7 9.63E − 03 0.6 −0.65 Amino acid Methylcysteine C4 H9 NO2 S HMDB02108 NA 1.7 1.38E − 02 2 0.65 Vitamin Pantothenic acid C9 H17 NO5 HMDB00210 C00864 1.7 6.53E − 03 1.4 0.65 Amino acid Ratio of urea/L-arginine CH4 N2 O/C6 H14 N4 O2 HMDB00294/HMDB00517 C00086/C00062 1.7 9.49E − 03 0.7 −0.64 Alkylamines Putrescine C4 H12 N2 HMDB01414 C00134 1.6 0.0159 0.8 −0.61 Amino acid L-Homoserine C4 H9 NO3 HMDB00719 C00263 1.6 0.0171 2.3 0.61 Amino acid L-Proline C5 H9 NO2 HMDB00162 C00148 1.6 0.0237 0.9 −0.61 Fatty acids Arachidonic acid C20 H32 O2 HMDB01043 C00219 1.6 0.0113 1.4 0.61 Fatty acids Docosahexaenoic acid C22 H32 O2 HMDB02183 C06429 1.5 0.0248 1.3 0.57 Organic acids Quinic acid C7 H12 O6 HMDB03072 C06746 1.5 0.0238 0.4 −0.57 Carbohydrates Alpha-lactose C12 H22 O11 HMDB00186 C00243 1.4 0.0432 0.7 −0.54 Lipids MG160 C19 H38 O4 HMDB11564 NA 1.4 0.0353 0.9 −0.54 NA 3-Hydroxypyridine C5 H5 NO NA NA 1.4 0.0359 0.9 −0.54 Carbohydrates L-Arabitol C5 H12 O5 HMDB01851 C00532 1.4 0.0344 0.9 −0.54 Fatty acids Myristic acid C14 H28 O2 HMDB00806 C06424 1.4 0.0405 1.2 0.53 Amino acid Homocysteine C4 H9 NO2 S HMDB00742 C00155 1.4 0.0367 0.8 −0.52 Organic acids Petroselinic acid C18 H34 O2 HMDB02080 C08363 1.4 0.0334 1.4 0.52 Lipids MG182 C21 H38 O4 HMDB11568 NA 1.4 0.0477 0.7 -0.51
