Combined Metabolomics and Network Toxicology to Explore the Molecular Mechanism of Phytolacca acinose Roxb-Induced Hepatotoxicity in Zebrafish Larvae in Vivo
Table 3
GO analysis of potential targets.
GO ID
Terms
Subgroup
Gene counts
P-value
GO:0042493
Response to drug
Biological process
18
3.58 × 10−14
GO:0032355
Response to estradiol
Biological process
10
3.61 × 10−10
GO:0001666
Response to hypoxia
Biological process
10
1.00 × 10−7
GO:0051926
Negative regulation of calcium ion transport
Biological process
5
2.98 × 10−7
GO:0045907
Positive regulation of vasoconstriction
Biological process
6
3.47 × 10−7
GO:0051384
Response to glucocorticoid
Biological process
7
5.49 × 10−19
GO:0045471
Response to ethanol
Biological process
8
5.61 × 10−18
GO:0035094
Response to nicotine
Biological process
6
7.37 × 10−7
GO:0007568
Aging
Biological process
9
9.59 × 10−7
GO:0043066
Negative regulation of apoptotic process
Biological process
13
1.16 × 10−6
GO:0045121
Membrane raft
Cellular component
10
2.35 × 10−7
GO:0043005
Neuron projection
Cellular component
10
1.18 × 10−6
GO:0005886
Plasma membrane
Cellular component
38
5.79 × 10−6
GO:0005887
Integral component of plasma membrane
Cellular component
20
8.52 × 10−6
GO:0005901
Caveola
Cellular component
6
3.60 × 10−5
GO:0005576
Extracellular region
Cellular component
20
3.60 × 10−5
GO:0016324
Apical plasma membrane
Cellular component
8
2.47 × 10−4
GO:0032279
Asymmetric synapse
Cellular component
3
4.98 × 10−4
GO:0005615
Extracellular space
Cellular component
16
5.18 × 10−4
GO:0000307
Cyclin-dependent protein kinase holoenzyme complex
