Tanshinone IIa Induces Autophagy and Apoptosis via PI3K/Akt/mTOR Axis in Acute Promyelocytic Leukemia NB4 Cells

Figure 4

Blocking autophagy reduced the anti-APL effect of TanIIa. (a) The Annexin V/PI staining of NB4 cells treated with TanIIa or Baf-A1 or both for 24 h. (b) The western blotting of autophagic proteins in NB4 cells treated with TanIIa or Baf-A1 or both for 24 h. (c) The relative quantification of autophagic proteins in NB4 cells treated with TanIIa or Baf-A1 or both for 24 h. Data were expressed as the mean ± SD of three independent experiments, , compared with the 0 μmol/L groups.

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