Antifungal Activity and Acute and Repeated-Dose Toxicity Study of Geranyl Cinnamate Ester in Mice

Table 2

Effect of the geranyl cinnamate ester (GCE) repeated-dose treatment (1, 2, and 4 mg/kg, p.o.) on female and male mice haemograms.

	Vehicle	GCE 1 mg/kg	GCE 2 mg/kg	GCE 4 mg/kg
Male
WBC (×10³/mm³)	1.65 ± 0.37	2.16 ± 0.52	3.10 ± 0.38	2.94 ± 0.87
Hb (g/dL)	12.83 ± 1.34	11.78 ± 1.23	13.73 ± 1.34	12.88 ± 1.52
HCT (%)	38.20 ± 5.61	31.94 ± 4.67	41.63 ± 5.59	38.36 ± 4.86
MCV (μm^3)	48.50 ± 1.44	47.20 ± 0.20	47.20 ± 0.62	47.20 ± 0.44
MCH (pg)	16.15 ± 0.27	17.88 ± 1.21	16.23 ± 1.02	15.86 ± 0.16
MCHC (g/dL)	33.55 ± 1.08	37.96 ± 2.71	33.70 ± 1.75	33.84 ± 0.49
RDW (%)	16.75 ± 0.73	16.26 ± 0.17	16.73 ± 0.64	16.32 ± 0.19
Platelets (×10³/mm³)	373.80 ± 60.64	358.50 ± 60.33	475.50 ± 27.84	112.70 ± 5.55^/#/§§
Erythrocytes (×10^6/mm^3)	6.76 ± 0.89	5.85 ± 1.52	6.93 ± 0.93	7.15 ± 0.34
Reticulocytes (%)	0.90 ± 0.08	1.20 ± 0.08	1.00 ± 0.08	0.80 ± 0.08^#
Neutrophils	6.00 ± 0.86	7.00 ± 0.86	7.00 ± 0.86	10.00 ± 0.86
Lymphocytes	93.00 ± 1.03	91.00 ± 1.03	91.00 ± 1.03	88.00 ± 1.03
Monocytes	1.00 ± 0.29	0.00 ± 0.29	1.00 ± 0.29	0.00 ± 0.29
Female
WBC (×10³/mm³)	2.13 ± 0.14	1.00 ± 0.20	1.95 ± 0.37	2.27 ± 0.60
Hb (g/dL)	13.60 ± 1.40	14.84 ± 0.49	15.26 ± 0.29	12.84 ± 0.71
HCT (%)	40.32 ± 5.03	45.18 ± 1.38	46.54 ± 1.05	36.72 ± 2.68
MCV (μm^3)	48.00 ± 0.57	47.20 ± 0.37	47.60 ± 0.24	47.20 ± 0.58
MCH (pg)	16.56 ± 0.70	15.44 ± 0.16	15.66 ± 0.10	16.58 ± 0.57
MCHC (g/dL)	34.28 ± 1.26	32.82 ± 0.28	32.82 ± 0.13	35.10 ± 0.86
RDW (%)	17.74 ± 1.37	16.04 ± 0.15	16.50 ± 0.21	16.12 ± 0.30
Platelets (×10³/mm³)	164.60 ± 44.89	137.60 ± 32.52	316.00 ± 115.5	253.00 ± 57.09
Erythrocytes (×10^6/mm^3)	6.71 ± 0.83	7.52 ± 0.23	7.75 ± 0.17	6.11 ± 0.44
Reticulocytes (%)	1.10 ± 0.11	1.50 ± 0.11	1.10 ± 0.11	1.00 ± 0.11^#
Neutrophils	10.00 ± 0.47	11.00 ± 0.47	12.00 ± 0.47	12.00 ± 0.47
Lymphocytes	86.00 ± 0.57	88.00 ± 0.57	88.00 ± 0.57	86.00 ± 0.57
Monocytes	2.00 ± 0.48	3.00 ± 0.48	1.00 ± 0.48	3.00 ± 0.48

Data are expressed as mean + SEM. One-way ANOVA post hoc Bonferroni (n = 5 mice/group). different from vehicle-treated group; ^# different from GCE 1 mg/kg-treated group; ^§ and ^§§ different from GCE 2 mg/kg-treated group. Hb: hemoglobin, RDW: red cell distribution width, HCT: haematocrit, MCV: mean corpuscular volume, MCH: mean cell hemoglobin, MCHC: mean cell corpuscular hemoglobin concentration, WBC: white blood cell counts, erythrocyte count, reticulocytes, E: eosinophils, M: monocytes, N: neutrophils, L: lymphocytes, and platelet counts.