Antifungal Activity and Acute and Repeated-Dose Toxicity Study of Geranyl Cinnamate Ester in Mice
Table 3
Relative organs’ weight (%) (brain, heart, thymus, spleen, adrenals, kidney, and liver) of the male and female mice treated with the geranyl cinnamate ester (GCE) at 1, 2, and 4 mg/kg (p.o.) for 28 days.
Vehicle
GCE 1 mg/kg
GCE 2 mg/kg
GCE 4 mg/kg
Male
Brain
1.18 ± 0.04
1.17 ± 0.01
1.16 ± 0.03
1.21 ± 0.02
Heart
0.39 ± 0.01
0.41 ± 0.01
0.43 ± 0.02
0.39 ± 0.01
Thymus
0.23 ± 0.01
0.21 ± 0.03
0.24 ± 0.01
0.23 ± 0.01
Spleen
0.29 ± 0.02
0.29 ± 0.01
0.31 ± 0.01
0.31 ± 0.01
Adrenals
0.020 ± 0.005
0.030 ± 0.004
0.030 ± 0.003
0.040 ± 0.004
Kidney
1.55 ± 0.02
1.60 ± 0.06
1.58 ± 0.07
1.69 ± 0.07
Liver
4.63 ± 0.26
4.84 ± 0.07
4.81 ± 0.07
4.73 ± 0.05
Female
Brain
1.35 ± 0.07
1.36 ± 0.07
1.39 ± 0.0
1.46 ± 0.03
Heart
0.39 ± 0.02
0.37 ± 0.01
0.42 ± 0.02
0.41 ± 0.02
Thymus
0.33 ± 0.02
0.32 ± 0.02
0.28 ± 0.02
0.30 ± 0.03
Spleen
0.51 ± 0.08
0.38 ± 0.02
0.35 ± 0.02
0.40 ± 0.01
Adrenals
0.050 ± 0.007
0.060 ± 0.004
0.070 ± 0.008
0.080 ± 0.006
Kidney
1.44 ± 0.13
1.29 ± 0.11
1.27 ± 0.09
1.26 ± 0.05
Liver
4.71 ± 0.13
4.08 ± 0.18
4.20 ± 0.17
4.16 ± 0.23
Data are expressed as mean + SEM. One-way ANOVA post hoc Bonferroni. different from the vehicle-treated group (corn oil, 10 mg/mL, p.o.).
