Simultaneous Determination of Ten Bioactive Components from Shenling Baizhu San in Rat Plasma by UHPLC-MS/MS: Application to a Comparative Pharmacokinetic Study in Normal and Two Models of Ulcerative Colitis Rats
Table 5
Mean pharmacokinetic parameters of active ingredients of SLBZP in normal and two model rats (Mean ± SD, n = 7 in normal and n = 8 in SDDR-UC and P-UC group).
Analyte
Group
Cmax (ng·mL−1)
Tmax (h)
t1/2 (h)
AUC(0-t) (ng·h·mL−1)
AUC(0-∞) (ng·h·mL−1)
CL (mL·h·kg−1)
Vz (mL·kg−1)
MRT(0-t) (h)
MRT(0-∞) (h)
PAN
Control
161.08 ± 124.22
3.18 ± 3.75
1.08 ± 0.64
897.55 ± 666.85
931.26 ± 667.45
5.37 ± 3.28
7.59 ± 4.28
7.11 ± 3.76
7.57 ± 3.81
SDDR-UC
106.82 ± 22.17
0.74 ± 0.47
1.82 ± 0.74
929.83 ± 172.24
983.53 ± 159.78
4.24 ± 0.6
11.1 ± 4.8
8.78 ± 2.23
9.61 ± 2.04
P-UC
52.93 ± 12.26
1.13 ± 0.92
1.34 ± 1.05
367.82 ± 222.72
406.79 ± 241.38
10.29 ± 7.1
20.26 ± 19.14
8.93 ± 5.33
9.91 ± 5.27
Rg1
Control
59.14 ± 47.02
4.64 ± 3.39
0.77 ± 0.46
393.38 ± 264.89
416.64 ± 265.22
6.71 ± 1.93
14.25 ± 10.68
8.41 ± 4.49
9.02 ± 4.67
SDDR-UC
8.02 ± 2.06
2.38 ± 2.09
0.67 ± 0.45
53.63 ± 17.95
55.78 ± 17.3
74.46 ± 42.94
69.92 ± 48.68
7.77 ± 4.76
8.18 ± 5.08
P-UC
4.5 ± 1.62
1.1 ± 1.03
0.39 ± 0.27
22.54 ± 15.52
27.02 ± 15
132.62 ± 71.81
76.87 ± 34.24
8.47 ± 6.88
9.93 ± 6.89
ATA-I
Control
14.81 ± 16.3
3.64 ± 3.58
1.17 ± 0.42
105.09 ± 55.63
113.37 ± 56.79
174.76 ± 284.12
223.16 ± 289.35
8.56 ± 4.46
9.38 ± 4.54
SDDR-UC
26.97 ± 4.42
0.35 ± 0.3
25.5 ± 9.35
330.81 ± 93.23
829.17 ± 150.77
8.4 ± 1.6
303.92 ± 113.96
9.18 ± 2.17
38.44 ± 11.05
P-UC
16.16 ± 7.09
0.11 ± 0.06
1.93 ± 1.32##
96.09 ± 63.88##
113.83 ± 66.19##
128.62 ± 159.26
223.47 ± 152.6
6.15 ± 4.31
7.64 ± 4.55##
ATA-III
Control
155.12 ± 170.33
3.82 ± 3.56
0.55 ± 0.22
1010.09 ± 596.3
1050.66 ± 598.91
64.02 ± 80.94
36.43 ± 37.03
8.79 ± 4.94
9.19 ± 4.99
SDDR-UC
43.45 ± 10.1
2.58 ± 3.95
1.68 ± 1.08
235.28 ± 109.21
283.36 ± 111.31
103.65 ± 50.43
231.28 ± 141.63
6.14 ± 3.75
7.54 ± 3.78
P-UC
52.15 ± 10.74
3.01 ± 3.91
0.78 ± 0.38
583.08 ± 315.6
615.63 ± 315.18
82.34 ± 97.68
105.26 ± 163.44
9.03 ± 4.57
9.64 ± 4.49
PA
Control
312.25 ± 94.35
4.29 ± 3.49
1.07 ± 0.85
4139.68 ± 2544.72
4388.37 ± 2664.79
2.48 ± 0.61
4.75 ± 2.66
8.69 ± 4.68
9.35 ± 4.79
SDDR-UC
292.12 ± 123.48
0.74 ± 0.81
3.45 ± 1.8
2713.48 ± 779.08
3227 ± 971.31
4.93 ± 2.24
21.46 ± 8.42
8.93 ± 2.52
11.59 ± 3.95
P-UC
251.2 ± 90.14
1.5 ± 0.83
1.98 ± 1.31
2319.51 ± 1382.55
2572.66 ± 1469.32
12.26 ± 14.82
20.11 ± 13.19
8.23 ± 4.27
9.57 ± 4.54
NEF
Control
1.33 ± 1.09
1.3 ± 1.94
1.02 ± 0.19
14 ± 4.24
14.86 ± 4.44
121.99 ± 30.82
179.57 ± 60.51
11.81 ± 0.57
12.6 ± 0.74
SDDR-UC
0.65 ± 0.07
3.82 ± 5.18
2.45 ± 1.42
10.19 ± 2.04
11.63 ± 2.34
152.39 ± 41.13
497.98 ± 238.53
10.9 ± 2.03
12.81 ± 2.76
P-UC
0.63 ± 0.35
1.25 ± 1.98
2.36 ± 0.62
7.55 ± 3.36
8.76 ± 3.56
240.36 ± 157.89
712.45 ± 228.39
10.46 ± 4.63
12.4 ± 4.75
NUC
Control
0.37 ± 0.19
9.15 ± 7.83
1.88 ± 0.81
6.33 ± 0.74
7.01 ± 0.58
29.17 ± 2.32
80.56 ± 37.25
11.88 ± 0.6
13.39 ± 1.12
SDDR-UC
0.29 ± 0.06
5.18 ± 7.9
2.6 ± 1.27
5.13 ± 0.97
5.98 ± 0.77
34.68 ± 5.68
133.56 ± 75.64
11.18 ± 2.17
13.39 ± 1.83
P-UC
0.36 ± 0.25
8.96 ± 10.25
5.7 ± 3.19
3.15 ± 2.43
6.72 ± 6.04
66.23 ± 55.8
418.15 ± 293.11
6.86 ± 5.32
13.66 ± 6.41
DG
Control
23.83 ± 5.32
3.05 ± 3.83
2.51 ± 0.83
259.36 ± 200.48
309.63 ± 231.1
0.86 ± 0.94
2.9 ± 3.35
8.77 ± 4.78
10.75 ± 4.91
SDDR-UC
14.67 ± 2.52
6.18 ± 8.21
1.13 ± 0.56
106.53 ± 59.84
123.81 ± 69.4
1.38 ± 0.91
1.65 ± 0.57
7.19 ± 4.03
8.18 ± 4.44
P-UC
49.54 ± 48.87
2.18 ± 4.05
0.88 ± 0.51
300.44 ± 204.52
321.14 ± 218.5
1.28 ± 2.09
0.92 ± 0.92
8.86 ± 4.77
9.46 ± 4.91
PD
Control
5.63 ± 1.29
3.17 ± 1.8
5.25 ± 3.35
71.99 ± 47.81
103.47 ± 62.5
1403.02 ± 832.03
10564.73 ± 4303.49
9.23 ± 5.51
13.96 ± 8.04
SDDR-UC
6.44 ± 1.49
1.11 ± 0.52
2.42 ± 1.29
52.57 ± 31.06
61.89 ± 29.36
2598.65 ± 1218.3
8646.19 ± 4540.35
9.4 ± 4.34
11.62 ± 5
P-UC
5.23 ± 0.9
1.49 ± 1.63
2.63 ± 1.79
39.16 ± 25.57
49.35 ± 28.22
3321.16 ± 2712.77
11129.86 ± 4568.62
7.15 ± 4.35
9.42 ± 5.26
ISL
Control
13.98 ± 10.03
3.94 ± 4.01
1.05 ± 0.48
125.15 ± 76.25
131.71 ± 76.69
497.73 ± 102.18
748.28 ± 252.22
7.83 ± 4.3
8.44 ± 4.24
SDDR-UC
110.61 ± 94.62
1.5 ± 0.74
1.62 ± 0.69
433.37 ± 151.42
464.88 ± 154.9
197.04 ± 53.73
439 ± 188.76
9.02 ± 2.32
10.15 ± 2.66
P-UC
10.3 ± 1.2#
17.25 ± 10.67
1.62 ± 1.22
136.84 ± 38.93##
159.02 ± 50.35##
659.45 ± 440.26#
1139.63 ± 645.37
12.74 ± 3.45
14.3 ± 4.19
Significantly different from the normal group, and . Significantly different from the SDDR-UC group, and .
