Evaluation of Antidiarrheal Activity of 80% Methanolic Extract of the Leaves of Cordia africana (Lamiaceae) in Mice

Table 2

Effect of crude extract of the leaves of Cordia africana on castor oil-induced diarrhea in mice.

Dose (mg/kg)	Onset of diarrhea (min)	No. of wet feces	Tot. no. of feces	Wt. of wet feces (gm)	Wt. of total feces (gm)	% Inhi. of defecation	%WWFO	%WTFO
Control	49.8 ± 3.75	7.3 ± 0.72	10.8 ± 0.70	1.36 ± 0.04	1.51 ± 0.05	—	—	—
80ME 100	81.2 ± 2.09^b	6.5 ± 0.43	9.2 ± 0.48	1.10 ± 0.06^b	1.13 ± 0.16^b	11	80.9	74.8
80ME 200	96.5 ± 2.49^b	1.7 ± 0.33^b	3.3 ± 0.42^b	0.29 ± 0.04^b	0.41 ± 0.04^b	76.7	21.3	27.2
80ME 400	109.7 ± 5.29^b	1.2 ± 0.40^b	2.7 ± 0.21^b	0.16 ± 0.05^b	0.25 ± 0.04^b	83.6	11.8	16.6
Loperamide 3	128.3 ± 9.10^b	0.7 ± 0.33^b	2.0 ± 0.37^b	0.10 ± 0.04^b	0.18 ± 0.05^b	90.4	7.4	11.9

Values are expressed as mean ± standard error of the mean (n = 6); analysis was done using one-way analysis of variance followed by Tukey post hoc test; ^bcompared with negative control values. wt. = weight; ME = methanol extract; min = minute; gm = gram; WWFO = weight of wet fecal output; WTFO = weight of total fecal output; Inhi. = inhibition. ; .