Review Article

Repetitive Transcranial Magnetic Stimulation for Neuropathic Pain on the Non-Motor Cortex: An Evidence Mapping of Systematic Reviews

Table 1

Characteristics of included systematic reviews.

Author and yearStudy designSearch dateObjectiveNumber of studies includedDesign and number of included studiesParticipants (n)

Yu et al., 2020 [28]SRMJanuary 2019To investigate the effect of non-invasive brain stimulation for SCI11RCT: 11274
Yang et al., 2020 [29]SRJune 2019To explore the effect of rTMS on different types of pain106RCT: 69; OLT: 16; CR: 213,264
Xu et al., 2020 [30]SRAugust 2020To assess the efficacy and safety of non-pharmacological therapies for CPSP11RCT: 11210
Moisset et al., 2020 [31]SRMJuly 2020To investigate the efficacy of neurostimulation techniques in migraine38RCT: 382,899
Moisset et al., 2020 [32]SRAugust 2019To propose all the alternative treatment options for NP131RCT: 13115,776
Liampas et al., 2020 [33]SRMNovember 2019To describe the prevalence and characteristics of CPSP and investigate the relevant management methods69NRNA
Gatzinsky et al., 2020 [22]SRJune 2019To review the efficacy and safety of rTMS on M132RCT: 24; CS: 8682 (RCT)
Aamir et al., 2020 [34]SRJune 2019To evaluate the effect of rTMSfor peripheral NP12RCT: 5; CS: 2; CR: 5188
Stilling et al., 2020 [35]SRSeptember 2018To review the use of TMS and tDCS for specific headache disorders34Randomized trials: 20; NRC/prospective cohort/OLT: 141,787
Ramger et al., 2019 [26]SR2018To evaluate the efficacy of rTMS and tDCS for CPSP6RCT: 1; prospective cohort: 1; CS: 2; cross-over: 2109
Hamid et al., 2019 [36]SR2018To explore the effect of rTMS on chronic refractory pain, especially in adults with central NP12RCT: 12350
Feng et al., 2019 [37]SRMSeptember 2018To evaluate the efficacy of rTMS and tDCS for migraine9RCT: 9276
O'Connell et al., 2018 [23]SRMOctober 2017To assess the efficacy of non-invasive cortical stimulation techniques on chronic pain94RCT: 942,983
Herrero babiloni et al., 2018 [27]SRNRTo explore the effect of TMS and tDCS for chronic OFP14RCT: 14228
Lan et al., 2017 [38]SRMApril 2017To explore the efficacy of TMS for migraine5RCT: 5313
Kumru et al., 2017 [39]SRAugust 2015To assess the role of rTMS or peripheral magnetic stimulation for NP39NR892
Goudra et al., 2017 [40]SRMNRTo evaluate the effect of rTMS for chronic pain9RCT: 6; prospective observational: 3183
Shirahige et al., 2016SRMNovember 11, 2015, to January 15, 2016To assess the effect of NIBS on migraine patients8RCT: 8296
Cragg et al., 2016 [42]SRMMay 2015To explore the predictors of placebo responses in central NP clinical trials39RCT: 391,153
Chen et al., 2016 [43]SRSeptember 2015To evaluate the antalgic effects of non-invasive physical modalities on CPSP16NA184
Jin et al., 2015 [44]SRMDecember 2014To evaluate the optimal parameters of rTMS for NP25RCT: 20; self-controlled: 5589
Galhardoni et al., 2015 [45]SR2014To review the studies on the analgesic effects of rTMS in chronic pain33RCT: 33842
Leung et al., 2009 [46]SRMAugust 2007To evaluate the overall effect of rTMS for NP and evaluate the effect of treatment parameters.5RCT: 5149

SRs: systematic reviews (with or without meta-analysis); SR: systematic review; SRM: systematic review with meta-analysis; NP: neuropathic pain; SCI: spinal cord injury; rTMS: repetitive transcranial magnetic stimulation; CPSP: central poststroke pain; M1: motor cortex; TMS: transcranial magnetic stimulation; tDCS: transcranial direct current stimulation; OFP: orofacial pain; NIBS: non-invasive brain stimulation; RCT: randomized controlled trial; OLT: open-label trial; CR: case report; NR: not reported; CS: case series; and NA: not available.