Antihyperuricemic Effect of Dendropanax morbifera Leaf Extract in Rodent Models

Table 4

Xanthine oxidase inhibition activity of Dendropanax morbifera leaf extracts and its active compounds.

Compounds	IC50 (µg/mL)^1	Relative activity (%)^2
DMLW	527.07 ± 10.25^a	1.95
DMLE-30	441.90 ± 5.15^b	2.32
DMLE-50	324.29 ± 1.08^c	3.16
DMLE-70	216.98 ± 7.41^d	4.73
CGA	69.07 ± 2.85^e	14.85
Rutin	>1000	—^3
ALP	10.25 ± 0.26^f	100.00

DMLW, water extract of Dendropanax morbifera leaf; DMLE-30, 30% ethanol extract of Dendropanax morbifera leaf; DMLE-50, 50% ethanol extract of Dendropanax morbifera leaf; DMLE-70, 70% ethanol extract of Dendropanax morbifera leaf; CGA, chlorogenic acid; ALP, allopurinol. ¹The concentration of each compound needed to inhibit 50% of xanthine oxidase activity. ²A ratio of IC₅₀ value compared with that of allopurinol. ³Not identified. ^a,b,c,dMean values with different superscript letters in the same row show significant differences at by one-way ANOVA.