Research Article
Wang-Bi Tablet Ameliorates DMM-Induced Knee Osteoarthritis through Suppressing the Activation of p38-MAPK and NF-κB Signaling Pathways in Mice
Figure 5
Effect of WBT on the phosphorylation of NF-κB p65 and P38. In drug treatment groups, KOA mice were treated daily by gavage with WBT from the first day of arthritis onset for 4 weeks. Mice in Sham and Mod groups were given 0.5% CMC-Na solvent during the same period. (a) Total proteins from the knee joints of mice were isolated and subjected to immunoblotting with indicated antibodies. (b) Densitometry quantification in (a) was analyzed by ImageJ software. Data are expressed as means ± SEM. All experiments are repeated for three times at least. , , and vs Sham group; , , and vs Mod group.
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