Evidence-Based Complementary and Alternative Medicine

Research Article

Use of Network Pharmacology to Investigate the Mechanism by Which Allicin Ameliorates Lipid Metabolism Disorder in HepG2 Cells

Table 3

GO enrichment analysis of the potential targets.
 TermGenes
Biological processMetabolismGM2A; CBR1; SULT2A1; AKR1B1; LSS; HSD17B1; HSD11B1; NR1H4; AKR1C2; AKR1C3; EPHX2; AKR1C1; STS; CYP2C9; PLA2G2A; BCHE; GSTM1; GSTM2; HPGDS; HMGCR; PLA2G10; PNMT
Energy pathwaysGM2A; CBR1; SULT2A1; AKR1B1; LSS; HSD17B1; AKR1C3; EPHX2; AKR1C1; STS; CYP2C9; PLA2G2A; BCHE; GSTM1; GSTM2; HPGDS; HMGCR; PLA2G10; PNMT
Bone remodelingRORA
TransportFABP6; APOA2; FABP7; FABP3; ALB; AKR1C2; GC; PCTP
Xenobiotic metabolismGSTM1
TranscriptionPPARD
Regulation of gene expression, epigeneticVDR
Cell communicationFABP4; PIK3R1; NR1H4; NR1H3; NR1H2; MAPKAPK2; RXRB; RXRA
Signal transductionFABP4; PIK3R1; NR1H4; NR1H3; NR1H2; MAPKAPK2; RXRB; RXRA
Protein metabolismLTA4H; DPEP1
Molecular functionLigand-dependent nuclear receptor activityPPARA; NR1H4; NR1H3; NR1H2; RXRB; RXRA
Transporter activityFABP6; APOA2; FABP7; GM2A; FABP3; ALB; AKR1C2; GC; PCTP
Catalytic activityLSS; HSD17B1; HSD11B1; AKR1C3; AKR1C1; STS; CYP2C9; HMGCR
Glutathione transferase activityGSTM1; GSTM2
Phospholipase activityPLA2G2A; PLA2G10
Oxidoreductase activityCBR1; AKR1B1; AKR1C2
Hydrolase activityEPHX2; BCHE; LTA4H
Transcription factor activityPPARD; VDR; PPARG
Protein serine/threonine kinase activityMAPKAPK2
DNA bindingRORA
Cellular componentExtracellular regionAPOA2; ALB; PLA2G2A; BCHE; GC; PLA2G10
CytoplasmFABP6; APOA2; FABP7; FABP4; FABP3; PPARA; CBR1; SULT2A1; AKR1B1; PIK3R1; HSD17B1; ALB; AKR1C3; EPHX2; AKR1C1; NR1H2; PLA2G2A; MAPKAPK2; GC; GSTM1; GSTM2; VDR; HPGDS; LTA4H; PCTP; PPARG
CytosolSULT2A1; AKR1B1; PIK3R1; AKR1C2; EPHX2; AKR1C1; MAPKAPK2; PCTP; PNMT
ExosomesAPOA2; GM2A; FABP3; CBR1; AKR1B1; ALB; EPHX2; GSTM2; LTA4H; DPEP1; PPARG
ExtracellularAPOA2; GM2A; FABP3; AKR1B1; ALB; PLA2G2A; BCHE; GC; HMGCR; PLA2G10
Endoplasmic reticulumLSS; HSD11B1; STS; CYP2C9; PLA2G2A; HMGCR; DPEP1
LysosomeAPOA2; GM2A; CBR1; AKR1B1; LSS; HSD17B1; ALB; STS
Extracellular spaceAKR1B1; ALB; PLA2G2A
NucleusESRRA; PPARA; PPARD; PIK3R1; ALB; NR1H4; NR1H3; AKR1C3; NR1H2; MAPKAPK2; RXRB; RXRA; VDR; LTA4H; PPARG; RORA
Plasma membranePIK3R1; STS; GC