Research Article

Use of Network Pharmacology to Investigate the Mechanism by Which Allicin Ameliorates Lipid Metabolism Disorder in HepG2 Cells

Table 4

Genes involved in each pathway.

TermCountGenes

Metabolic pathways14PLA2G10, PNMT, HSD17B1, HMGCR, CYP2C9, EPHX2, LSS, AKR1C3, CBR1, AKR1B1, HSD11B1, PLA2G2A, LTA4H, HPGDS
PPAR signaling pathway11PPARA, APOA2, PPARD, RXRB, RXRA, PPARG, FABP3, FABP4, FABP7, FABP6, NR1H3
Arachidonic acid metabolism8AKR1C3, CBR1, PLA2G10, CYP2C9, PLA2G2A, EPHX2, LTA4H, HPGDS
Metabolism of xenobiotics by cytochrome P4508GSTM1, GSTM2, AKR1C2, CBR1, SULT2A1, CYP2C9, HSD11B1, AKR1C1
Steroid hormone biosynthesis6AKR1C3, AKR1C2, STS, HSD17B1, HSD11B1, AKR1C1
Chemical carcinogenesis6GSTM1, GSTM2, CBR1, SULT2A1, CYP2C9, HSD11B1
Bile secretion4SULT2A1, HMGCR, RXRA, NR1H4
Insulin resistance4NR1H2, PPARA, PIK3R1, NR1H3
Hepatitis C4PPARA, RXRA, PIK3R1, NR1H3
Nonalcoholic fatty liver disease (NAFLD)4PPARA, RXRA, PIK3R1, NR1H3
Linoleic acid metabolism3PLA2G10, CYP2C9, PLA2G2A
Thyroid cancer3RXRB, RXRA, PPARG
Non-small cell lung cancer3RXRB, RXRA, PIK3R1