Desensitization of TRPV1 Involved in the Antipruritic Effect of Osthole on Histamine-Induced Scratching Behavior in Mice

Figure 4

Molecular docking of osthole combined with TRPV1. (a) The docking site based on the structure of TRPV1 protein active site. The green band represents TRPV1, and the yellow stick means the key residue of the active site. The overlapping display of 48 docking conformations of osthole on the activated site of TRPV1 is shown. The blue represents the docking conformation. (b) Combination model of osthole with TRPV1. Left: the surface of TRPV1, and the yellow stick represents osthole. Right: the gray band represents TRPV1, and the yellow stick represents osthole. (c–e) Chemical bond of osthole combined with TRPV1. (c) The hydrophobic interaction of osthole and TRPV1. Orange represents highly hydrophobic area, blue represents highly hydrophilic area, and the yellow ball-stick represents osthole. (d) The two-dimension schematic representation of the interaction between osthole and residues of TRPV1 protein’s activated site. (e) The three-dimensional interaction structure of osthole and TRPV1.

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