Zingiberensis Newsaponin Inhibits the Malignant Progression of Hepatocellular Carcinoma via Suppressing Autophagy Moderated by the AKR1C1-Mediated JAK2/STAT3 Pathway

Figure 1

Zingiberensis newsaponin (ZnS) suppresses the proliferation of HCC cells in a dose-dependent manner. (a) The proliferation of HCC cell lines (Huh7 and SMMC7721) measured by Cell Counting Kit-8 (CCK-8) assay. Cells were treated with different concentrations of ZnS (0.1, 0.2, 0.4, 0.8, and 1.6 µM) for 48 h. (b)-(c) The IC50 value of ZnS determined by a proliferation curve at 48 h posttreatment in Huh7 and SMMC7721 cells.  < 0.01 and  < 0.001 vs. the control group.  < 0.05 and  < 0.01 vs. the 0.1 µM ZnS group.  < 0.01 vs. the 0.2 µM ZnS group.

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