Effect of Sijunzi Pills on Pharmacokinetics of Omeprazole in Beagle Dogs by HPLC-UV: A Herb-Drug Interaction Study

Table 2

The main pharmacokinetic parameters of omeprazole in beagle dogs. Group A: omeprazole alone administration; group B: SJZPs combined with omeprazole (n = 6, mean ± SD).

Parameters	Group A	Group B
Cmax (ng/mL)	366.69 ± 83.92	592.41 ± 42.74
Tmax (h)	1.88 ± 0.26	2.17 ± 0.41
t1/2 (h)	1.85 ± 0.31	1.89 ± 0.32
CLz/F (L/h/kg)	0.50 ± 0.11	0.30 ± 0.04
Vz/F (L/h)	1.73 ± 0.35	0.83 ± 0.23
AUC(0−t) (ng·h/mL)	1359.81 ± 240.22	2229.67 ± 299.72
AUC(0−∞) (ng·h/mL)	1386.37 ± 249.04	2268.83 ± 291.43

Abbreviations: t_1/2, half-life; T_max, time of peak concentration. C_max, peak concentration. CL_z/F, clearance. V_z/F, apparent volume of distribution. AUC_(0−t), area under the curve of 0-t time. AUC_(0−∞), area under the curve of 0-infinity time (compared with group A, and ).