Saposhnikoviae Radix Enhanced the Angiogenic and Anti-Inflammatory Effects of Huangqi Chifeng Tang in a Rat Model of Cerebral Infarction

<div>Effects of HQCFT and HQCFT-SR on the protein expression levels of MMP-9, VEGF, and VEGFR2 in the brain tissue of rats subjected to MCAO. (a) MMP-9 expression in rat brain tissue, (b) VEGF expression in rat brain tissue, and (c) VEGFR2 expression in rat brain tissue. The sham group and model group were administered normal saline for 14 days. The HQCFT group and HQCFT-SR group were treated with HQCFT extract and HQCFT without SR for 14 days, respectively, and the dose was 1.6 g/kg and 1.31 g/kg daily, respectively. Data are expressed as the mean ± SD (<i>n</i> = 3). <sup>∗∗∗</sup><svg height="11.7782pt" id="M22" style="vertical-align:-3.42938pt" version="1.1" viewbox="-0.0498162 -8.34882 50.7895 11.7782" width="50.7895pt" xmlns="http://www.w3.org/2000/svg" xmlns:xlink="http://www.w3.org/1999/xlink"><g transform="matrix(.013,0,0,-0.013,0,0)"><path d="M570 304C570 398 525 448 414 448C385 448 343 445 312 434L329 511L321 518C297 504 262 482 244 460L233 411C195 397 159 381 128 358L135 332C160 347 189 360 224 373L111 -147C97 -210 84 -218 17 -231L13 -257L254 -247L259 -218L233 -216C183 -212 177 -202 189 -142L218 -1C238 -10 266 -12 283 -12C351 3 429 48 483 105C543 168 570 242 570 304ZM482 289C482 161 380 33 304 33C278 33 248 51 233 69L303 396C326 400 352 403 369 403C428 403 482 380 482 289Z"></path></g><g transform="matrix(.013,0,0,-0.013,11.342,0)"><path d="M512 -3V55L134 254V256L512 456V514L75 281V230L512 -3Z"></path></g><g transform="matrix(.013,0,0,-0.013,22.605,0)"><path d="M241 635C89 635 35 457 35 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555 205 550 205 499V114C205 42 199 34 109 27V0H384Z"></path></g></svg> vs. the sham operation group, <span class="nowrap"><svg height="15.3614pt" id="M23" style="vertical-align:-3.833899pt" version="1.1" viewbox="-0.0498162 -11.5275 49.4726 15.3614" width="49.4726pt" xmlns="http://www.w3.org/2000/svg" xmlns:xlink="http://www.w3.org/1999/xlink"><g transform="matrix(.0091,0,0,-0.0091,0,-5.741)"><path d="M457 455H370L403 612H360L326 455H218L252 612H210L175 455H77L68 394H161L132 257H31L20 196H117L77 19H120L159 196H268L230 19H272L311 196H402L412 257H325L355 394H447L457 455ZM313 394L283 257H175L204 394H313Z"></path></g><g transform="matrix(.013,0,0,-0.013,4.946,-1.651)"><path d="M570 304C570 398 525 448 414 448C385 448 343 445 312 434L329 511L321 518C297 504 262 482 244 460L233 411C195 397 159 381 128 358L135 332C160 347 189 360 224 373L111 -147C97 -210 84 -218 17 -231L13 -257L254 -247L259 -218L233 -216C183 -212 177 -202 189 -142L218 -1C238 -10 266 -12 283 -12C351 3 429 48 483 105C543 168 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Evidence-Based Complementary and Alternative Medicine

fig5

Figure 5

Figure 5: Saposhnikoviae Radix Enhanced the Angiogenic and Anti-Inflammatory Effects of Huangqi Chifeng Tang in a Rat Model of Cerebral Infarction 