Saposhnikoviae Radix Enhanced the Angiogenic and Anti-Inflammatory Effects of Huangqi Chifeng Tang in a Rat Model of Cerebral Infarction

<div>Effects of HQCFT and HQCFT-SR on the activity of HIF-1<i>α</i>, NLRP3, caspase 1, IL-1<i>β</i>, TNF-<i>α,</i> and IL-6 in the serum of rats subjected to MCAO. (a) HIF-1<i>α</i> content in rat serum. (b) NLRP 3 content in rat serum. (c) Caspase 1 content in rat serum. (d) IL-1<i>β</i> content in rat serum. (e) IL-6 content in rat serum. (f) TNF-<i>α</i> content in rat serum. Data are expressed as the mean ± SD (<i>n</i> = 12). <sup>∗∗∗</sup><svg height="11.7782pt" id="M46" style="vertical-align:-3.42938pt" version="1.1" viewbox="-0.0498162 -8.34882 50.7895 11.7782" width="50.7895pt" xmlns="http://www.w3.org/2000/svg" xmlns:xlink="http://www.w3.org/1999/xlink"><g transform="matrix(.013,0,0,-0.013,0,0)"><path d="M570 304C570 398 525 448 414 448C385 448 343 445 312 434L329 511L321 518C297 504 262 482 244 460L233 411C195 397 159 381 128 358L135 332C160 347 189 360 224 373L111 -147C97 -210 84 -218 17 -231L13 -257L254 -247L259 -218L233 -216C183 -212 177 -202 189 -142L218 -1C238 -10 266 -12 283 -12C351 3 429 48 483 105C543 168 570 242 570 304ZM482 289C482 161 380 33 304 33C278 33 248 51 233 69L303 396C326 400 352 403 369 403C428 403 482 380 482 289Z"></path></g><g transform="matrix(.013,0,0,-0.013,11.342,0)"><path d="M512 -3V55L134 254V256L512 456V514L75 281V230L512 -3Z"></path></g><g transform="matrix(.013,0,0,-0.013,22.605,0)"><path d="M241 635C89 635 35 457 35 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555 205 550 205 499V114C205 42 199 34 109 27V0H384Z"></path></g></svg> vs. the sham operation group, <svg height="15.3614pt" id="M47" style="vertical-align:-3.833899pt" version="1.1" viewbox="-0.0498162 -11.5275 53.9209 15.3614" width="53.9209pt" xmlns="http://www.w3.org/2000/svg" xmlns:xlink="http://www.w3.org/1999/xlink"><g transform="matrix(.0091,0,0,-0.0091,0,-5.741)"><path d="M457 455H370L403 612H360L326 455H218L252 612H210L175 455H77L68 394H161L132 257H31L20 196H117L77 19H120L159 196H268L230 19H272L311 196H402L412 257H325L355 394H447L457 455ZM313 394L283 257H175L204 394H313Z"></path></g><g transform="matrix(.0091,0,0,-0.0091,4.432,-5.741)"><path d="M457 455H370L403 612H360L326 455H218L252 612H210L175 455H77L68 394H161L132 257H31L20 196H117L77 19H120L159 196H268L230 19H272L311 196H402L412 257H325L355 394H447L457 455ZM313 394L283 257H175L204 394H313Z"></path></g><g transform="matrix(.013,0,0,-0.013,9.395,-1.651)"><path d="M570 304C570 398 525 448 414 448C385 448 343 445 312 434L329 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602Z"></path></g><g transform="matrix(.013,0,0,-0.013,58.414,0)"><path d="M384 0V27C293 34 287 42 287 114V635C232 613 172 594 109 583V559L157 557C201 555 205 550 205 499V114C205 42 199 34 109 27V0H384Z"></path></g></svg> vs. the HQCFT group.</div>

Evidence-Based Complementary and Alternative Medicine

fig8

Figure 8

Figure 8: Saposhnikoviae Radix Enhanced the Angiogenic and Anti-Inflammatory Effects of Huangqi Chifeng Tang in a Rat Model of Cerebral Infarction 