Protective Effect of NGR1 against Glutamate-Induced Cytotoxicity in HT22 Hippocampal Neuronal Cells by Upregulating the SIRT1/Wnt/β-Catenin Pathway

Figure 2

NGR1 alleviated apoptosis and oxidative stress in the glutamate-induced HT22 cells. The levels of SOD and GSH were measured by assay kits. The level of ROS measured by flow cytometry (a). The apoptotic ratio detected by flow cytometry (b). The expressions of Bcl-2 and Bax in cells measured by Western blotting (c). was considered significant compared to control (); ## was considered significant compared to glutamate treatment ().

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(b)

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