Protective Effect of NGR1 against Glutamate-Induced Cytotoxicity in HT22 Hippocampal Neuronal Cells by Upregulating the SIRT1/Wnt/β-Catenin Pathway

Figure 6

NGR1 activates the Wnt/β-catenin pathway by upregulating SIRT1. The expression of Wnt-1, β-catenin, and cyclin D1 in HT22 cells measured by Western blotting (a). was considered significant compared to control (); ## was considered significant compared to Glu treatment (); △△ was considered significant compared to Glu and NGR1 treatment (). $$ was considered significant compared to Glu, NGR1, and nicotinamide treatment ().

(a)

(b)