Network Pharmacology Interpretation of Fuzheng–Jiedu Decoction against Colorectal Cancer

Table 2

Information on 30 core targets.

Gene	Description	UniProt	Degree	Source
STAT3	Signal transducer and activator of transcription 3	P40763	84	Predicted
INS	Insulin	P01308	84	Predicted
TP53	Cellular tumor antigen p53	P04637	84	Validated
VEGFA	Vascular endothelial growth factor A	P15692	83	Validated
AKT1	RAC-alpha serine/threonine-protein kinase	P31749	83	Predicted
TNF	Tumor necrosis factor	P01375	82	Validated
IL6	Interleukin-6	P05231	82	Validated
JUN	Transcription factor AP-1	P05412	81	Validated
EGF	Pro-epidermal growth factor	P01133	81	Validated
CASP3	Caspase-3	P42574	80	Predicted
MAPK3	Mitogen-activated protein kinase 3	P27361	79	Predicted
MAPK1	Mitogen-activated protein kinase 1	P28482	79	Validated
MAPK8	Mitogen-activated protein kinase 8	P45983	79	Validated
SRC	proto-oncogene tyrosine-protein kinase Src	P12931	78	Predicted
IGF1	Insulin-like growth factor I	P05019	78	Predicted
CCND1	G1/S-specific cyclin D1	P24385	78	Predicted
ESR1	Estrogen receptor	P03372	77	Validated
EGFR	Epidermal growth factor receptor	P00533	77	Validated
PTEN	Phosphatase and tensin homolog	P60484	76	Predicted
MTOR	Serine/threonine-protein kinase mTOR	P42345	75	Predicted
FOS	Proto-oncogene c-Fos	P01100	74	Predicted
PTGS2	Prostaglandin G/H synthase 2	P35354	73	Validated
CXCL8	Interleukin-8	P10145	73	Predicted
HRAS	GTPase HRas	P01112	73	Predicted
CDH1	Cadherin-1	P12830	73	Predicted
BCL2L1	Bcl-2-like protein 1	Q07817	72	Predicted
FN1	Fibronectin	P02751	71	Predicted
MMP9	Matrix metalloproteinase-9	P14780	71	Predicted
ERBB2	Receptor tyrosine-protein kinase erbB-2	P04626	70	Predicted
JAK2	Tyrosine-protein kinase JAK2	O60674	69	Predicted