Review Article

A Systematic Review and Meta-Analysis of the Effects of Herbal Medicine Buyang Huanwu Tang in Patients with Poststroke Fatigue

Table 1

Characteristics of the included studies.

Study (first author, year)Subjects (herbal/control)Stroke type (ischemic/hemorrhagic)InterventionsMain outcomes (herbal/control)Duration of outcome assessment (weeks)Adverse events (herbal/control)
Herbal medicinesControl group

Song, 201170 (35/35)53/17Conventional therapies + rehabilitation therapies for stroke + BHT variant 1
4 weeks
Conventional therapies + rehabilitation therapies for stroke 4 weeksFSS
3.15 ± 1.71/4.09 ± 1.86
IL-1β (23/19)
21.3 ± 9.5/26.7 ± 10.3 (pg/ml)
IL-6 (23/19)
16.2 ± 8.3/21.7 ± 9.2 (pg/ml)
TNF-α (23/19)
20.6 ± 14.3/29.8 ± 15.2 (pg/ml)
40/0
Liang, 201692 (46/46)57/35Conventional therapies + rehabilitation therapies for stroke + BHT variant 2
4 weeks
Conventional therapies + rehabilitation therapies for stroke 4 weeksFSS
3.39 ± 0.73/5.33 ± 5.45
4Unreported
Xu, 201862 (31/31)UnreportedConventional therapies + rehabilitation therapies for stroke + BHT variant 3
4 weeks
Conventional therapies + rehabilitation therapies for stroke 4 weeksTCER
29/31 (93.55%)/19/31 (61.29%)
4Unreported
Yin, 202080 (40/40)UnreportedConventional therapies + rehabilitation therapies for stroke + BHT variant 4
4 weeks
Conventional therapies + rehabilitation therapies for stroke 4 weeksFSS
3.27 ± 0.81/5.41 ± 0.56
4Unreported
Duan, 202160 (30/30)UnreportedConventional therapies + rehabilitation therapies for stroke + BHT variant 5
4 weeks
Conventional therapies + rehabilitation therapies for stroke 4 weeksFSS
2.73 ± 0.23/3.81 ± 0.24
4Unreported
Ye, 201863 (33/30)UnreportedBHT variant 5
4 weeks
Conventional therapies for stroke 4 weeksFSS
2.73 ± 0.24/3.81 ± 0.24
4Unreported

BHT: Buyang Huanwu Tang; FSS: Fatigue Severity Scale; TCER: total clinical efficacy rate.