Using the Symptom Patient Similarity Network to Explore the Difference between the Chinese and Western Medicine Pathways of Ischemic Stroke and its Comorbidities
Table 4
Top 20 enriched pathways of symptom genes in M3.
Symptom pathway in M3
Symptom pathway value
Drug pathway value
Herb pathway value
AGE-RAGE SP in diabetic complications
3.3876E-17
ns
2.00999E-29
Neuroactive ligand-receptor interaction
1.32395E-16
9.33419E-48
ns
Alzheimer’s disease
3.67245E-16
5.1187E-06
5.56899E-05
Calcium signaling pathway
5.41417E-16
7.04619E-24
ns
Amyotrophic lateral sclerosis (ALS)
3.09577E-15
0.000130295
3.13695E-10
Pathways in cancer
4.09088E-15
ns
1.4964E-32
Hepatitis B
3.44822E-14
ns
1.61268E-31
Bladder cancer
2.22937E-13
ns
7.08838E-17
Proteoglycans in cancer
3.97422E-13
ns
3.49664E-17
Malaria
4.0587E-13
ns
3.28241E-16
Pancreatic cancer
8.48407E-13
ns
4.62234E-21
cAMP signaling pathway
1.77595E-12
4.10807E-14
7.44568E-05
Colorectal cancer
1.48163E-11
ns
5.75226E-16
HIF-1 signaling pathway
2.86538E-11
ns
4.7202E-19
EGFR tyrosine kinase inhibitor resistance
3.02218E-11
ns
3.82288E-17
Endocrine resistance
3.49548E-11
ns
3.29809E-23
MicroRNAs in cancer
9.68694E-11
ns
9.46322E-11
Prostate cancer
3.02359E-10
ns
1.5772E-23
FoxO signaling pathway
3.21659E-10
ns
5.3789E-25
Glioma
4.70998E-10
ns
2.33281E-14
AGE-RAGE SP in diabetic complications: AGE-RAGE signaling pathway in diabetic complications; ns: not significant.
