Oridonin Dose-Dependently Modulates the Cell Senescence and Apoptosis of Gastric Cancer Cells

Figure 3

Low-dose oridonin induced GC cellular senescence. (a) MGC803 and AGS cells treated with 5 and 3 μM oridonin, respectively, for 48 h and then maintained cells with oridonin-free medium for additional 4 days. Senescent cells are identified by senescence-associated β-galactosidase activity assay. (b) Quantitative analysis of senescent cells with the percentage of β-gal-positive cells per unit area (n = 3, bars are the mean ± SD, p < 0.01, p < 0.001).

(a)

(b)