Oridonin Dose-Dependently Modulates the Cell Senescence and Apoptosis of Gastric Cancer Cells

Figure 7

Oridonin triggered apoptosis by inducing autophagy in GC cells. The expression of LC3 in the AGS (a) and HGC27 (b) cells exposed to oridonin was compared by immunofluorescence and Western blot; (c) the expression of LC3 examined by Western blot. (d)-(e) AGS cells are treated with high-dose oridonin, with or without pretreated with BafA1 (0.5 nM, 12 h), and then, the apoptosis and expression of apoptotic markers in AGS cells are assayed.

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