Network Pharmacology and Molecular Docking Suggest the Mechanism for Biological Activity of Rosmarinic Acid

Table 2

Target genes of RosA from CTD database.

No.	Gene ID	Gene symbol	Description
1	10544	PROCR	Protein C receptor
2	6868	Adam17	Adam metallopeptidase domain 17
3	5970	RELA	RELA proto-oncogene, NF-kB subunit
4	7040	TGFB1	Transforming growth factor beta 1
5	7124	TNF	Tumor necrosis factor
6	3553	IL1B	Interleukin 1 beta
7	3569	IL6	Interleukin 6
8	5468	PPARG	Peroxisome proliferator-activated receptor gamma
9	847	CAT	Catalase
10	4780	NFE2L2	Nuclear factor, erythroid 2 like 2
11	1277	COL1A1	Collagen type I alpha 1 chain
12	1401	CRP	C-reactive protein
13	2919	CXCL1	C-X-C motif chemokine ligand 1
14	59	ACTA2	Actin alpha 2, smooth muscle
15	836	CASP3	Caspase 3
16	1490	CCN2	Cellular communication network factor 2
17	1281	COL3A1	Collagen type III alpha 1 chain
18	2876	GPX1	Glutathione peroxidase 1
19	9446	GSTO1	Glutathione S-transferase omega 1
20	3162	HMOX1	Heme oxygenase 1
21	9817	KEAP1	Kelch-like ECH-associated protein 1
22	4313	MMP2	Matrix metallopeptidase 2
23	4318	MMP9	Matrix metallopeptidase 9
24	4843	NOS2	Nitric oxide synthase 2
25	1728	NQO1	NAD(P)H-quinone dehydrogenase 1
26	5054	SERPINE1	Serpin family E member 1
27	6647	SOD1	Superoxide dismutase 1
28	6648	SOD2	Superoxide dismutase 2
29	7498	XDH	Xanthine dehydrogenase
30	9131	AIFM1	Apoptosis inducing factor mitochondria associated 1
31	595	CCND1	Cyclin D1
32	968	CD68	CD68 molecule
33	1312	COMT	catechol-O-methyltransferase
34	1674	DES	Desmin
35	1786	DNMT1	DNA methyltransferase 1
36	2335	FN1	Fibronectin 1
37	2353	FOS	Fos proto-oncogene, AP-1 transcription factor subunit
38	2875	GPT	Glutamic--pyruvic transaminase
39	3146	HMGB1	High mobility group box 1
40	3725	JUN	Jun proto-oncogene, AP-1 transcription factor subunit
41	157855	KCNU1	Potassium calcium-activated channel subfamily U member 1
42	4128	MAOA	Monoamine oxidase A
43	4129	MAOB	Monoamine oxidase B
44	6885	MAP3K7	Mitogen-activated protein kinase kinase kinase 7
45	5594	MAPK1	Mitogen-activated protein kinase 1
46	5595	MAPK3	Mitogen-activated protein kinase 3
47	5599	MAPK8	Mitogen-activated protein kinase 8
48	5601	MAPK9	Mitogen-activated protein kinase 9
49	4353	MPO	Myeloperoxidase
50	4615	MYD88	MYD88 innate immune signal transduction adaptor
51	4846	NOS3	Nitric oxide synthase 3
52	4968	OGG1	8-Oxoguanine DNA glycosylase
53	8505	PARG	Poly (ADP-ribose) glycohydrolase
54	7099	TLR4	Toll-like receptor 4
55	7431	VIM	Vimentin