Network Pharmacology and Molecular Docking Suggest the Mechanism for Biological Activity of Rosmarinic Acid

Table 3

Key protein topological parameters of protein interaction network.

Name	Degree	Betweenness centrality	Closeness centrality
TNF	53	0.06924682	0.8630137
IL6	51	0.05915435	0.84
CASP3	49	0.08868983	0.81818182
JUN	46	0.03570932	0.7875
MAPK8	44	0.02681408	0.76829268
IL1B	42	0.01914187	0.75
MMP9	42	0.02381611	0.75
MAPK3	41	0.01732055	0.74117647
TLR4	40	0.01981721	0.73255814
CAT	38	0.07900048	0.71590909
MAPK1	38	0.0134504	0.71590909
HMOX1	36	0.01175721	0.7
FN1	36	0.01346746	0.7
FOS	34	0.02316259	0.68478261
TGFB1	34	0.03713298	0.68478261
SERPINE1	31	0.01151125	0.66315789
SOD2	30	0.03539503	0.64948454
NQO1	24	0.01251491	0.61165049