Study of the Antimalarial Activity of the Leaf Extracts and Fractions of Persea americana and Dacryodes edulis and Their HPLC Analysis

Table 2

Effect of the extracts on parasitemia of P. berghei-infected mice in Rane’s curative antimalarial model.

Group	Treatment	% parasitemia		% inhibition of parasitemia
		Day 3	Day 8
1	100 mg/kg PA	70.80 ± 3.71	46.80 ± 3.44	33.90 ± 2.13
2	200 mg/kg PA	69.80 ± 3.54	41.80 ± 4.85	40.11 ± 5.10
3	400 mg/kg PA	69.40 ± 1.44	33.20 ± 4.91	52.16 ± 2.77
4	100 mg/kg DE	73.40 ± 1.50	66.60 ± 2.46	9.26 ± 0.08
5	200 mg/kg DE	67.00 ± 3.51	34.20 ± 3.18	48.96 ± 2.11
6	400 mg/kg DE	60.60 ± 2.94	26.00 ± 2.05	57.10 ± 1.98
7	ACT	78.80 ± 3.58	24.40 ± 5.02	69.04 ± 3.02
8	Control	71.20 ± 2.47	79.60 ± 5.4	−11.80 ± 1.07

Data are mean ± standard error of mean (SEM) (n = 5); , , as compared with control group; % inhibition of parasitemia = (% parasitemia on day 3 − % parasitemia on day 8/% parasitemia on day 3) × 100; DE = D. edulis leaf extract; PA = P. americana leaf extract.