Study of the Antimalarial Activity of the Leaf Extracts and Fractions of Persea americana and Dacryodes edulis and Their HPLC Analysis

Table 3

Effect of the extracts on the Hb and PCV of P. berghei-infected mice in Rane's curative antimalarial model.

Group	Treatment	Hb (mg/dL)				PCV (%)
		Day 0	Day 3	Day 8	% change in Hb^#	Day 0	Day 3	Day 8	% change in PCV^#
1	100 mg/kg PA	11.00 ± 0.25	9.24 ± 0.11	9.78 ± 0.15	5.84 ± 0.08	40.80 ± 0.58	30.80 ± 1.85	35.80 ± 0.92	16.23 ± 0.06
2	200 mg/kg PA	11.26 ± 0.23	8.42 ± 0.61	10.28 ± 0.21	22.09 ± 0.23	41.20 ± 0.80	28.40 ± 1.21	35.80 ± 0.66	26.06 ± 0.07
3	400 mg/kg PA	11.40 ± 0.27	7.72 ± 0.30	10.34 ± 0.18	33.94 ± 0.12	41.80 ± 1.36	31.60 ± 0.93	36.80 ± 1.16	16.46 ± 0.40
4	100 mg/kg DE	11.08 ± 0.13	7.72 ± 0.29	9.46 ± 0.24	22.54 ± 0.14	42.25 ± 1.10	32.00 ± 1.08	33.50 ± 0.95	4.69 ± 0.80
5	200 mg/kg DE	11.20 ± 0.12	8.46 ± 0.63	10.50 ± 0.12	24.11 ± 0.23	42.20 ± 0.80	32.80 ± 1.66	35.80 ± 0.73	9.15 ± 0.90
6	400 mg/kg DE	11.00 ± 0.09	7.80 ± 0.36	10.86 ± 0.19	39.23 ± 0.25	40.40 ± 0.68	32.20 ± 1.56	36.40 ± 0.68	13.04 ± 0.33
7	Standard drug (ACT)	11.28 ± 0.71	7.84 ± 0.29	11.22 ± 0.13	43.11 ± 0.17	41.40 ± 0.74	32.60 ± 1.60	39.80 ± 0.66	22.09 ± 0.87
8	Control (infected but untreated)	10.98 ± 0.13	7.06 ± 0.28	6.90 ± 0.31	−2.27 ± 0.05	41.80 ± 0.58	28.60 ± 1.32	24.00 ± 1.44	−16.08 ± 0.05

Data are mean ± standard error of mean (SEM) (n = 5); , , as compared with control group; ^#% change in Hb or PCV is that of day 3 and day 8.