In Vitro and In Silico Evaluation for the Inhibitory Action of O. basilicum Methanol Extract on α-Glucosidase and α-Amylase

Figure 4

Binding interface between plausible inhibitors and the α-glucosidase enzyme: (a) E-isoeugenol, (b) linalool, (c) beta-D-glucopyranoside,5-methyl-2-1-methylethyl-phenyl, and (d) uvasol. All amino acids that are within 5 Ǻ from the ligand are shown as sticks. The rest of the protein is shown in an 80% transparent cartoon model. Polar contacts are shown in yellow, whereas other possible contacts are in blue.

(a)

(b)

(c)

(d)