Unveiling the Mechanism of Principal Drugs of Lianpu Drink on Chronic Gastritis by Network Pharmacology

Table 1

The information of target proteins of “CR” predicted by network pharmacology analyses.

Uniprot no.	Protein name	Gene name	Closeness centrality	Degree	Betweenness centrality
Q9Y6K9	NF-kappa-B essential modulator	IKBKG	0.2195	23	0.0539
Q9Y4K3	TNF receptor-associated factor 6	TRAF6	0.1998	22	0.0686
P35222	Catenin beta-1	CTNNB1	0.1781	22	0.0565
P19838	Nuclear factor NF-kappa-B p105 subunit	NFKB1	0.2001	21	0.0360
P00533	Epidermal growth factor receptor	EGFR	0.1994	19	0.0594
Q04206	Transcription factor p65	RELA	0.2037	19	0.0255
O15111	Inhibitor of nuclear factor kappa-B kinase subunit alpha	CHUK	0.2225	18	0.0790
P25963	NF-kappa-B inhibitor alpha	NFKBIA	0.2163	18	0.0391
O14920	Inhibitor of nuclear factor kappa-B kinase subunit beta	IKBKB	0.2150	15	0.0182
P05412	Transcription factor AP-1	JUN	0.2060	13	0.0580
P31749	RAC-alpha serine/threonine-protein kinase	AKT1	0.2009	13	0.0344
Q99558	Mitogen-activated protein kinase kinasekinase 14	MAP3K14	0.2037	13	0.0207
P25445	Tumor necrosis factor receptor superfamily member 6	FAS	0.1964	11	0.0725
P09874	Poly [ADP-ribose] polymerase 1	PARP1	0.2071	11	0.0374
P35968	Vascular endothelial growth factor receptor 2	KDR	0.1910	11	0.0350
P19438	Tumor necrosis factor receptor superfamily member 1A	TNFRSF1A	0.1718	11	0.0237
Q99759	Mitogen-activated protein kinase kinasekinase 3	MAP3K3	0.1793	10	0.0235
O15350	Tumor protein p73	TP73	0.1954	9	0.0152
P04150	Glucocorticoid receptor	NR3C1	0.1796	8	0.0323
Q13546	Receptor-interacting serine/threonine-protein kinase 1	RIPK1	0.2052	7	0.0935
Q14790	Caspase-8	CASP8	0.1748	6	0.0102
P41279	Mitogen-activated protein kinase kinasekinase 8	MAP3K8	0.1714	6	0.0000
Q9HC29	Nucleotide-binding oligomerization domain-containing protein 2	NOD2	0.1747	5	0.0118
Q13191	E3 ubiquitin-protein ligase CBLB	CBLB	0.1984	5	0.0088
P29466	Caspase-1	CASP1	0.1750	4	0.0263
Q16236	Nuclear factor erythroid 2-related factor 2	NFE2L2	0.1971	4	0.0088
Q30201	Hereditary hemochromatosis protein	HFE	0.1976	3	0.0205
P35869	Aryl hydrocarbon receptor	AHR	0.1822	3	0.0191
P55957	BH3-interacting domain death agonist	BID	0.1862	3	0.0073
P35228	Nitric oxide synthase	NOS2	0.1970	3	0.0059
P49281	Natural resistance-associated macrophage protein 2	SLC11A2	0.1970	3	0.0059
P40763	Signal transducer and activator of transcription 3	STAT3	0.1725	3	0.0059
P45983	Mitogen-activated protein kinase 8	MAPK8	0.1813	3	0.0047
P45984	Mitogen-activated protein kinase 9	MAPK9	0.1721	3	0.0043
Q16539	Mitogen-activated protein kinase 14	MAPK14	0.1921	3	0.0039