Sendeng-4 Suppressed Melanoma Growth by Induction of Autophagy and Apoptosis

Figure 4

Sendeng-4 promote cell apoptosis and inhibit MAPK and PI3K/AKT signaling pathways. (a) A375 and A875 cells were treated with different concentrations of Sengdeng-4 for 12 h Western blot analysis was performed to measure protein levels of phospho-ERK (p-ERk), total ERK, phospho-JNK (p-JNK), total JNK, p-AKT, total AKT, BAX, and BCL-2 in A375 cells. Β-actin was used as an internal control. (b) Quantification of (a).

(a)

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