Composition of the Essential Oil Thymus schimperi and Evaluation of Its Acute and Subacute Toxicity in Wistar Albino Rats: In Silico Toxicity Studies
Table 3
Acute toxicity of single oral doses of Thymus schimperi essential oil in rats.
Conc. (C) (mg/kg)
Log (C)
Alive (%)
Dead (%)
Prop., p
Corr., p
Logit (p)
Probit (p)
Symptoms
0
100
0
0
None
300
2.5
100
0
0
None
600
2.8
100
0
0
None
900
3.0
80
20
0.2
0.2
−1.4
3.6
Hypoactivity, piloerection, convulsion
1200
3.1
80
20
0.2
0.2
−1.4
3.6
Hypoactivity, piloerection, convulsion
1500
3.2
20
80
0.8
0.8
1.4
6.4
Hypoactivity, piloerection, convulsion
2000
3.3
0
100
1
Hypoactivity, piloerection, convulsion
Slope
11.9
11.9
Intercept
−37.0
−32.0
Test value
0.0
5.0
Log (C%)
3.1
3.1
LD 50
1284.2
1284.2
After the dose, all rats treated were carefully examined for signs of toxicity and lethality up to 14°d.Conc. (C): concentration, log (C): logarithm of the concentration, alive (%): number of live rats in percent, and dead: number of dead rats in percent.
