Composition of the Essential Oil Thymus schimperi and Evaluation of Its Acute and Subacute Toxicity in Wistar Albino Rats: In Silico Toxicity Studies

Table 4

Effects of different oral single doses of Thymus schimperi essential oil in rats for acute toxicity.

Parameters	Control	T. schimperi treatment of essential oil
		300 mg/kg	600 mg/kg	900 mg/kg	1200 mg/kg
Bodyweight loss (%)
Day 7	5.78 ± 0.07	5.00 ± 0.05	4.71 ± 0.03	3.43 ± 0.03^a	2.24 ± 0.05^a
Day 14	10.02 ± 0.11	7.01 ± 0.04	6.30 ± 0.04^a	5.23 ± 0.04^a	3.85 ± 0.05^b
Organs’ weight (g)
Liver	6.72 ± 1.01	6.71 ± 1.08	7.45 ± 1.06	7.87 ± 0.08^b	7.91 ± 0.09^b
Kidney	1.52 ± 0.04	1.47 ± 0.03	1.58 ± 0.05	1.81 ± 0.06^b	1.94 ± 0.06^b
Heart	0.43 ± 0.05	0.42 ± 0.04	0.40 ± 0.03	0.41 ± 0.04	0.41 ± 0.04
Spleen	0.52 ± 0.09	0.55 ± 0.08	0.54 ± 0.07	0.55 ± 0.08	0.62 ± 0.08^a

Data are expressed as mean ± SEM, n = 5 for each group; ^asignificant at compared to the control only; ^bsignificant at compared to the control and 300 mg/kg group; ^csignificant at compared to the control, 600, and 9 000 mg/kg; ^dsignificant at compared to the 900 and 1200 mg/kg.