Network Pharmacology-Based Analysis of the Underlying Mechanism of Huajiao for Pain Relief

Table 1

Top 20 analgesic components of Huajiao.

No.	Name	Structure	Gastrointestinal absorption	log^Kp (cm/s)	Bioavailability score
1	(6RS)-(2E,7E,9E)-6-Hydroxy-N-(2-hydroxy-2-methylpropyl)-11-oxo-2,7,9-dodecatrienamide		High	−7.73	0.55
2	(2E)-6,6-Dimethoxy-N-(2-hydroxy-2-methylpropyl)-2-hexenamide		High	−7.50	0.55
3	(2E,7E,9E)-N-(2-Hydroxy-2-methylpropyl)-11-ethoxy-6-hydroxy-dodeca-2,7,9-trienamide		High	−7.41	0.55
4	(2E,4E,8Z,11E)-2’-Hydroxy-N-isobutyl-2,4,8,11-tetradecatetraenamide		High	−7.41	0.55
5	Tetradecatetraenamide		High	−5.56	0.55
6	N-[2-(3,4-Dimethoxyphenyl) ethyl]-3-phenyl-acrylamide		High	−6.23	0.55
7	Hydroxy-α-sanshool		High	−5.90	0.55
8	Hydroxy-γ-sanshool		High	−5.61	0.55
9	(2E,7E,9E)-N-(2-Hydroxy-2-methylpropyl)-6-ethoxy-11-hydroxy-dodeca-2,7,9-trienamide		High	−7.41	0.55
10	Arnothianamide		High	−5.66	0.55
11	(11RS)-(2E,7E,9E)-11-hyHydroxydroxy-N-(2-hydroxy-2-methylpropyl)-6-oxo-2,7,9-dodecatrienamide		High	−7.78	0.55
12	(2E,6E,8E)-N-(2-Hydroxy-2-methylpropyl)-10-hydroxy-5-oxo-undeca-2,6,8-trienamide		High	−7.90	0.55
13	(2E,4E,9E,11E)-N-(2-hydroxy-2-methypropyl)-8-hydroxy-13-oxo-2,4,9,11-tetradecatetraenamide		High	−7.44	0.55
14	(6RS,11RS)-(2E,7E,9E)-N-(2-Hydroxy-2-methylpropyl)-6,11-dioxo-2,7,9-dodecatrienamide		High	−7.71	0.55
15	γ-Sanshool		High	−4.52	0.55
16	Rutin		High	−7.05	0.55
17	Hydroxy-β-sanshool		High	−5.90	0.55
18	(2E,4E,8Z,11Z)-N-(2-Hydroxy-2-methylpropyl)-2,4,8,11-tetradecatetraenamide		High	−5.56	0.55
19	3,5,6-Trihydroxy-7,4´-dimethoxy flavone		High	−6.31	0.55
20	β-Sanshool		High	−4.82	0.55