Network Pharmacology-Based Analysis of the Underlying Mechanism of Huajiao for Pain Relief

Table 2

The dataset of 66 proteins for pathway enrichment analysis.

ID	Protein name	Degree	Closeness centrality	Betweenness centrality
P42574	Caspase-3	23	0.31	0.01
Q13547	Histone deacetylase 1	20	0.31	0.01
P78527	DNA-dependent protein kinase catalytic subunit	21	0.32	0.01
P42338	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform	13	0.31	0.01
P05412	Transcription factor AP-1	16	0.33	0.01
P23219	Prostaglandin G/H synthase 1	44	0.34	0.01
Q16665	Hypoxia-inducible factor 1-alpha	22	0.30	0.01
P30305	M-phase inducer phosphatase 2	24	0.33	0.01
P49336	Cyclin-dependent kinase 8	26	0.32	0.01
P07900	Heat shock protein HSP 90-alpha	41	0.37	0.02
P50613	Cyclin-dependent kinase 7	13	0.32	0.01
P04629	High affinity nerve growth factor receptor	20	0.33	0.01
P23458	Tyrosine-protein kinase JAK1	28	0.34	0.01
P62993	Growth factor receptor-bound protein 2	20	0.32	0.01
O60674	Tyrosine-protein kinase JAK2	30	0.34	0.01
Q99558	Mitogen-activated protein kinase kinase kinase 14	26	0.33	0.01
P42345	Serine/threonine-protein kinase mTOR	25	0.33	0.01
P35354	Prostaglandin G/H synthase 2	51	0.34	0.01
P09874	Poly [ADP-ribose] polymerase 1	40	0.35	0.02
P06213	Insulin receptor	26	0.33	0.01
P31749	RAC-alpha serine/threonine-protein kinase	22	0.33	0.01
P12931	Proto-oncogene tyrosine-protein kinase Src	28	0.36	0.01
P49841	Glycogen synthase kinase-3 beta	31	0.35	0.01
Q96GD4	Aurora kinase B	19	0.32	0.01
P00918	Carbonic anhydrase 2	76	0.37	0.01
P18031	Tyrosine-protein phosphatase nonreceptor type 1	53	0.35	0.01
P22303	Acetylcholinesterase	65	0.36	0.01
P11511	Aromatase	83	0.36	0.02
P11362	Fibroblast growth factor receptor 1	18	0.30	0.01
P09619	Platelet-derived growth factor receptor beta	23	0.33	0.01
P04049	RAF protooncogene serine/threonine-protein kinase	35	0.33	0.02
O15111	Inhibitor of nuclear factor kappa-B kinase subunit alpha	23	0.32	0.01
O14920	Inhibitor of nuclear factor kappa-B kinase subunit beta	27	0.34	0.01
O14965	Aurora kinase A	29	0.34	0.01
P24941	Cyclin-dependent kinase 2	41	0.34	0.01
Q07869	Peroxisome proliferator-activated receptor alpha	58	0.34	0.01
P06493	Cyclin-dependent kinase 1	35	0.34	0.01
P09917	Arachidonate 5-lipoxygenase	55	0.36	0.01
P04150	Glucocorticoid receptor	54	0.36	0.01
P43405	Tyrosine-protein kinase SYK	25	0.34	0.01
P56817	Beta-secretase 1	36	0.36	0.01
P0DMS8	Adenosine receptor A3	35	0.35	0.01
P30542	Adenosine receptor A1	47	0.36	0.01
Q16539	Mitogen-activated protein kinase 14	38	0.37	0.01
P45983	Mitogen-activated protein kinase 8	25	0.33	0.01
Q00987	E3 ubiquitin-protein ligase Mdm2	26	0.34	0.01
P05067	Amyloid-beta precursor protein	29	0.34	0.02
P00533	Epidermal growth factor receptor	57	0.37	0.03
P32246	C–C chemokine receptor type 1	19	0.31	0.01
P28482	Mitogen-activated protein kinase 1	29	0.34	0.01
P08581	Hepatocyte growth factor receptor	29	0.34	0.01
P06401	Progesterone receptor	53	0.35	0.01
P03372	Estrogen receptor	66	0.34	0.02
O43570	Carbonic anhydrase 12	40	0.35	0.01
P00915	Carbonic anhydrase 1	62	0.37	0.01
P35968	Vascular endothelial growth factor receptor 2	45	0.36	0.02
P00519	Tyrosine-protein kinase ABL1	24	0.33	0.01
P28845	Corticosteroid 11-beta-dehydrogenase isozyme 1	67	0.37	0.01
O00519	Fatty-acid amide hydrolase 1	47	0.35	0.01
P41594	Metabotropic glutamate receptor 5	34	0.36	0.01
P10275	Androgen receptor	108	0.38	0.05
P37231	Peroxisome proliferator-activated receptor gamma	39	0.34	0.01
O75762	Transient receptor potential cation channel subfamily A member 1	38	0.35	0.01
Q8NER1	Transient receptor potential cation channel subfamily V member 1	49	0.36	0.01
P34972	Cannabinoid receptor 2	57	0.35	0.01
P21554	Cannabinoid receptor 1	40	0.36	0.01