Network Pharmacology-Based Analysis of the Underlying Mechanism of Huajiao for Pain Relief

Table 3

Druggability information of 5 amide alkaloids.

No.	GPCR ligand	Ion channel modulator	Kinase inhibitor	Nuclear receptor ligand	Protease inhibitor	Enzyme inhibitor	OWAR ()	TPSA	Lipinski rules
1	0.31	0.38	−0.23	0.41	0.3	0.53	0.83	86.62	√
2	0.41	0.4	0	0.42	0.31	0.43	1.64	78.79	√
3	0.44	0.38	0	0.4	0.29	0.45	1.54	89.78	√
4	0.41	0.36	−0.01	0.33	0.23	0.46	1.64	78.79	√
5	0.43	0.41	−0.05	0.39	0.24	0.5	1.02	89.78	√

GPCR, G-protein coupled receptors; OWAR, octyl alcohol/water allocation ratio; TPSA, topological polar surface area.