Study on the Antianxiety Mechanism of Suanzaoren Decoction Based on Network Pharmacology and Molecular Docking

Table 1

The main active material parameters of SZRT.

Herb	Molecule name	OB (%)	DL	Structure
GC	DFV	32.76	0.18
GC	Glycyrrhiza flavonol A	41.28	0.6
GC	Pinocembrin	64.72	0.18
GC	1-Methoxyphaseollidin	69.98	0.64
GC	Glypallichalcone	61.6	0.19
GC	Licopyranocoumarin	80.36	0.65
GC	Licochalcone B	76.76	0.19
GC	Glycyrol	90.78	0.67
GC	Icos-5-enoic acid	30.7	0.2
GC	18α-Hydroxyglycyrrhetic acid	41.16	0.71
GC	Gadelaidic acid	30.7	0.2
GC	Shinpterocarpin	80.3	0.73
GC	Formononetin	69.67	0.21
GC	Liquiritin	65.69	0.74
GC	Naringenin	59.29	0.21
GC, CX	Sitosterol	36.91	0.75
GC	HMO	38.37	0.21
GC	Gancaonin H	50.1	0.78
GC	Vestitol	74.66	0.21
GC	Glycyroside	37.25	0.79
GC	Calycosin	47.75	0.24	1
GC	Isoglycyrol	44.7	0.84	1
GC	Licorice glycoside E	32.89	0.27	2
GC	Xambioona	54.85	0.87	3
GC	Quercetin	46.43	0.28	4
GC	Kanzonol F	32.47	0.89	5
GC	Jaranol	50.83	0.29	6
GC	(-)-Medicocarpin	40.99	0.95	7
GC	Licochalcone a	40.79	0.29	8
GC	Euchrenone	30.29	0.57
GC	Odoratin	49.95	0.3
ZM	Marmesin	50.28	0.18
GC	Isorhamnetin	49.6	0.31
ZM	Coumaroyltyramine	112.9	0.2
GC	Glabranin	52.9	0.31
ZM, GC	Kaempferol	41.88	0.24
GC	Licochalcone G	49.25	0.32
ZM	Anhydroicaritin	45.41	0.44
GC	Quercetin der.	46.45	0.33
ZM	Asperglaucide	58.02	0.52
GC	Inflacoumarin A	39.71	0.33
ZM	Chrysanthemaxanthin	38.72	0.58
GC	Medicarpin	49.22	0.34
ZM	Icariin I	41.58	0.61
GC	Glepidotin B	64.46	0.34	4
ZM	Hippeastrine	51.65	0.62
GC	Glepidotin A	44.72	0.35
ZM	Stigmasterol	43.83	0.76
GC	Glyzaglabrin	61.07	0.35
ZM	Anemarsaponin F_qt	60.06	0.79
GC	Licocoumarone	33.21	0.36
ZM	Diosgenin	80.88	0.81
GC	Lupiwighteone	51.64	0.37
ZM	Mangiferolic acid	36.16	0.84
GC	Eurycarpin A	43.28	0.37
ZM	Anemarsaponin E_qt	30.67	0.86
GC	Dehydroglyasperins C	53.82	0.37
ZM	Timosaponin B III_qt	35.26	0.87
GC	Gancaonin G	60.44	0.39
ZM	Anemarsaponin C_qt	35.5	0.87
GC	Glyasperin C	45.56	0.4
FL	ergosta-7, 22E-dien-3beta-ol	43.51	0.72
GC	Gancaonin A	51.08	0.4
FL	Poricoic acid B	30.52	0.75
GC	Glyasperins M	72.67	0.59
FL	Poricoic acid C	38.15	0.75
GC	Sigmoidin-B	34.88	0.41
FL	Hederagenin	36.91	0.75
GC	Isotrifoliol	31.94	0.42
FL	Poricoicacid A	30.61	0.76
GC	Licoisoflavone	41.61	0.42
FL	Cerevisterol	37.96	0.77
GC	Isolicoflavonol	45.17	0.42
FL	Trametenolic acid	38.71	0.8
GC	Glyasperin B	65.22	0.44
FL	7, 9(11)-Dehydropachymic acid	35.11	0.81
GC	Glabrene	46.27	0.44
FL	Ergosterol peroxide	40.36	0.81
GC	Phaseolinisoflavan	32.01	0.45
FL	Pachymic acid	33.63	0.81
GC	Gancaonin B	48.79	0.45
FL	Dehydroeburicoic acid	44.17	0.83
GC	Licoricone	63.58	0.47
CX	Mandenol	42	0.19
GC	Glycyrin	52.61	0.47
CX	Senkyunone	47.66	0.24
GC	Glabridin	53.25	0.47
CX	Perlolyrine	65.95	0.27
GC	Licoagroisoflavone	57.28	0.49
CX	Myricanone	40.6	0.51
GC	Glabrone	52.51	0.5
CX	FA	68.96	0.71
GC	Kanzonols W	50.48	0.52
CX	Wallichilide	42.31	0.71
GC	Inermine	75.18	0.54
SZR	(S)-Coclaurine	42.35	0.24
GC	Glyasperin F	75.84	0.54
SZR	Zizyphusine	41.53	0.55
GC	Licoisoflavanone	52.47	0.54
SZR	Jujuboside A_qt	34.96	0.62
GC	Semilicoisoflavone B	48.78	0.55
SZR	Daucosterol	36.91	0.75
GC	Licoisoflavone B	38.93	0.55
SZR	Phytosterol	36.91	0.75
GC	3′-Methoxyglabridin	46.16	0.57
SZR	Swertisin	31.83	0.75
GC	Licoagrocarpin	58.81	0.58
SZR	Ceanothic acid	33.41	0.77
GC	Phaseol	78.77	0.58
SZR	Sanjoinenine	67.28	0.79
GC	3,22-Dihydroxy-11-oxo-delta (12)-oleanene-27-alpha-methoxycarbonyl-29-oic acid	34.32	0.55
SZR, GC	Mairin	55.38	0.78
GC	1,3-Dihydroxy-8,9-Dimethoxy-6-Benzofurano[3,2-c]chromenone	62.9	0.53
GC	3-(3,4-Dihydroxyphenyl)-5,7-dihydroxy-8-(3-methylbut-2-enyl) chromone	66.37	0.41
GC	8-Prenylated eriodictyol	53.79	0.4
GC	5,7-Dihydroxy-3-(4-Methoxyphenyl)-8-(3-methylbut-2-enyl) chromone	30.49	0.41
GC	(2R)-7-Hydroxy-2-(4-hydroxyphenyl) chroman-4-one	71.12	0.18
GC	2-(3,4-Dihydroxyphenyl)-5,7-dihydroxy-6-(3-methylbut-2-enyl) chromone	44.15	0.41
GC	(2S)-6-(2,4-Dihydroxyphenyl)-2-(2-hydroxypropan-2-yl)-4-methoxy-2,3-dihydrofuro[3,2-g]chromen-7-one	60.25	0.63
GC	3-(2,4-Dihydroxyphenyl)-8-(1,1-dimethylprop-2-enyl)-7-hydroxy-5-methoxy-coumarin	59.62	0.43
GC	7,2′,4′-Trihydroxy-5-methoxy-3-arylcoumarin	83.71	0.27
GC	1,3-Dihydroxy-9-methoxy-6-benzofurano[3,2-c]chromenone	48.14	0.43
GC	(E)-3-[3,4-Dihydroxy-5-(3-methylbut-2-enyl) phenyl]-1-(2,4-dihydroxyphenyl) prop-2-en-1-one	46.27	0.31
GC	8-(6-Hydroxy-2-benzofuranyl)-2,2-dimethyl-5-chromenol	58.44	0.38
GC	(2S)-2-[4-Hydroxy-3-(3-methylbut-2-enyl) phenyl]-8,8-dimethyl-2,3-dihydropyrano[2,3-f]chromen-4-one	31.79	0.72
ZM	(Z)-3-(4-Hydroxy-3-methoxy-phenyl)-N-[2-(4-hydroxyphenyl) ethyl]acrylamide	118.35	0.26
FL	(2R)-2-[(3S,5R,10S,13R,14R,16R,17R)-3,16-Dihydroxy-4,4,10,13,14-pentamethyl-2,3,5,6,12,15,16,17-octahydro-1H-cyclopenta[a]phenanthren-17-yl]-5-isopropyl-hex-5-enoic acid	31.07	0.82
FL	(2R)-2-[(3S,5R,10S,13R,14R,16R,17R)-3,16-Dihydroxy-4,4,10,13,14-pentamethyl-2,3,5,6,12,15,16,17-octahydro-1H-cyclopenta[a]phenanthren-17-yl]-6-methylhept-5-enoic acid	30.93	0.81
GC	7-Methoxy-2-methyl isoflavone	42.56	0.2
FL	3β-Hydroxy-24-methylene-8-lanostene-21-oic acid	38.7	0.81
GC	(2S)-7-Hydroxy-2-(4-hydroxyphenyl)-8-(3-methylbut-2-enyl) chroman-4-one	36.57	0.32
GC	2-[(3R)-8,8-Dimethyl-3,4-dihydro-2H-pyrano[6,5-f]chromen-3-yl]-5-methoxyphenol	36.21	0.52
GC	(E)-1-(2,4-Dihydroxyphenyl)-3-(2,2-dimethylchromen-6-yl) prop-2-en-1-one	39.62	0.35
GC	3′-Hydroxy-4′-O-Methylglabridin	43.71	0.57
GC	6-Prenylated eriodictyol	39.22	0.41
GC	7-Acetoxy-2-methylisoflavone	38.92	0.26
FL	(2R)-2-[(5R,10S,13R,14R,16R,17R)-16-Hydroxy-3-keto-4,4,10,13,14-pentamethyl-1,2,5,6,12,15,16,17-octahydrocyclopenta[a]phenanthren-17-yl]-5-isopropyl-hex-5-enoic acid	38.26	0.82