Evidence-Based Complementary and Alternative Medicine

Research Article

Study on the Antianxiety Mechanism of Suanzaoren Decoction Based on Network Pharmacology and Molecular Docking

The related pathway of the antianxiety effect of SZRT.


Term	ID	value	Input gene name

Cytokine-cytokine receptor interaction	hsa04060	5.86E − 07	CCL2\|CXCL8\|IL1B\|TNF\|IL10
IL-17 signaling pathway	hsa04657	2.47E − 07	CCL2\|CXCL8\|IL1B\|TNF
NOD-like receptor signaling pathway	hsa04621	3.06E − 06	CCL2\|CXCL8\|IL1B\|TNF
NF-kappa B signaling pathway	hsa04064	2.60E − 05	CXCL8\|IL1B\|TNF
Toll-like receptor signaling pathway	hsa04620	2.92E − 05	CXCL8\|IL1B\|TNF
C-type lectin receptor signaling pathway	hsa04625	2.92E − 05	IL10\|IL1B\|TNF
MAPK signaling pathway	hsa04010	0.0006	IL1B\|TNF\|TP53
Neuroactive ligand-receptor interaction	hsa04080	1.15E − 06	ADRB2\|GABRA2\|GABRA1\|NR3C1\|DRD1
Amphetamine addiction	hsa05031	7.41E − 08	SLC6A3\|MAOB\|MAOA\|DRD1
Dopaminergic synapse	hsa04728	9.32E − 07	SLC6A3\|MAOB\|MAOA\|DRD1
Serotonergic synapse	hsa04726	3.91E − 05	MAOB\|MAOA\|HTR3A
Morphine addiction	hsa05032	1.98E − 05	GABRA2\|GABRA1\|DRD1
Phenylalanine metabolism	hsa00360	5.09E − 05	MAOB\|MAOA
Tryptophan metabolism	hsa00380	2.13E − 06	MAOB\|CYP1A2\|MAOA
Morphine addiction	hsa05032	0.0001	GABRA2\|GABRA1\|DRD1
Cocaine addiction	hsa05030	2.12E − 08	SLC6A3\|MAOB\|MAOA\|DRD1