Huoxue Jiedu Huayu Formula Alleviates Cell Pyroptosis in Contralateral Kidneys of 6-Month-Old UUO Rats through the NLRP3/Caspase-1/IL-1β Pathway

Figure 2

The treatment with Huayu Jiedu formula and spironolactone, respectively, improved kidney functions of 6-month-old UUO rats, although accompanied by increased systolic blood pressure and the ratio of kidney to body weight. (a) After Huoxue Jiedu Huayu formula and spironolactone intervention separately, systolic blood pressure declined 5 and 6 months after UUO compared with UUO group. vs. Sham group, , . vs. UUO group,  < 0.05,  < 0.01. (b, c) Kidney weight and the ratio of kidney to body weight increased in three groups but not in Sham group. , . (d, e) Compared with the UUO group, the levels of serum creatinine and urea went down in both Huoxue Jiedu Huayu and spironolactone group. ,  < 0.001.

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