Huoxue Jiedu Huayu Formula Alleviates Cell Pyroptosis in Contralateral Kidneys of 6-Month-Old UUO Rats through the NLRP3/Caspase-1/IL-1<i>β</i> Pathway

<div>Huoxue Jiedu Huayu formula and spironolactone alleviated inflammatory lesions and fibrosis in the contralateral kidneys of 6-month-old UUO rats. (a) Inflammatory cell infiltration was observed in Sham group by HE staining, which was inhibited in Huoxue Jiedu Huayu formula and spironolactone groups. (b) Macrophages labeled with CD68 were observed by immunofluorescent staining, which were quantitatively analyzed by histogram. 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(c) Masson stain shows collagen deposition, which is in blue. Compared with the UUO group, collagen deposition observably reduced in Huoxue Jiedu Huayu formula and spironolactone groups.</div>

Evidence-Based Complementary and Alternative Medicine

fig3

Figure 3

Figure 3: Huoxue Jiedu Huayu Formula Alleviates Cell Pyroptosis in Contralateral Kidneys of 6-Month-Old UUO Rats through the NLRP3/Caspase-1/IL-1<i>β</i> Pathway 

Figure 3 | Huoxue Jiedu Huayu Formula Alleviates Cell Pyroptosis in Contralateral Kidneys of 6-Month-Old UUO Rats through the NLRP3/Caspase-1/IL-1β Pathway 