Huoxue Jiedu Huayu Formula Alleviates Cell Pyroptosis in Contralateral Kidneys of 6-Month-Old UUO Rats through the NLRP3/Caspase-1/IL-1<i>β</i> Pathway

<div>Intervention by Huoxue Jiedu Huayu formula and spironolactone obviously inhibited the NLRP3/caspase-1/IL-1<i>β</i> signal pathway of pyroptosis in the contralateral kidneys of 6-month-old UUO rats. (a) The protein expressions of NLRP3, caspase-1, and IL-1<i>β</i> were shown by immunofluorescence. NLRP3 and IL-1<i>β</i> are displayed in red, while caspase-1 is displayed in green. (b) Western blotting, respectively, demonstrate the expression of NLRP3, caspase-1, and IL-1<i>β</i>. Protein expression was quantitatively analyzed by histogram. 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Evidence-Based Complementary and Alternative Medicine

fig6

Figure 6

Figure 6: Huoxue Jiedu Huayu Formula Alleviates Cell Pyroptosis in Contralateral Kidneys of 6-Month-Old UUO Rats through the NLRP3/Caspase-1/IL-1<i>β</i> Pathway 

Figure 6 | Huoxue Jiedu Huayu Formula Alleviates Cell Pyroptosis in Contralateral Kidneys of 6-Month-Old UUO Rats through the NLRP3/Caspase-1/IL-1β Pathway 