Berberine Reduces Renal Cell Pyroptosis in Golden Hamsters with Diabetic Nephropathy through the Nrf2-NLRP3-Caspase-1-GSDMD Pathway

<div>HE staining results of golden hamster kidney tissue in each group (×400). The red arrow in the figure mainly reflects the increase of mesangial matrix in the glomerulus; the yellow arrow reflects the degeneration and disorder of the cells in the renal tubules and the nuclear pyknosis of some tubular epithelial cells; the black arrow reflects the kidney infiltration of interstitial inflammatory cells. <i>Note.</i> (a) Control group; (b) model group; (c) BBR high-dose group; (d) BBR low-dose group; (e) irbesartan group.</div>

Evidence-Based Complementary and Alternative Medicine

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Figure 1

Figure 1: Berberine Reduces Renal Cell Pyroptosis in Golden Hamsters with Diabetic Nephropathy through the Nrf2-NLRP3-Caspase-1-GSDMD Pathway 