Berberine Reduces Renal Cell Pyroptosis in Golden Hamsters with Diabetic Nephropathy through the Nrf2-NLRP3-Caspase-1-GSDMD Pathway

Table 8

Comparison of NLRP3, Caspase-1, GSDMD, and IL-1β mRNA in the kidney tissues of golden hamsters in each group ( ± S).

Group	NLRP3	Caspase-1	GSDMD	IL-1β
Control group	0.34 ± 0.03	0.33 ± 0.18	0.05 ± 0.02	0.38 ± 0.04
Model group	1.66 ± 0.22	1.81 ± 0.04	2.51 ± 0.46	2.18 ± 1.45^∗
BBR-H group	0.81 ± 0.16	1.07 ± 0.07	0.70 ± 0.24	0.92 ± 0.33
BBR-L group	1.00 ± 0.39	1.27 ± 0.44	1.22 ± 0.47	1.39 ± 0.34
Irbesartan group	0.57 ± 0.18	0.81 ± 0.15	0.73 ± 0.29	0.33 ± 0.18

Note. Compared with the control group, ; compared with the model group, .