Combination of Xuesaitong and Aspirin Based on the Antiplatelet Effect and Gastrointestinal Injury: Study Protocol for a Randomized Controlled Noninferiority Trial

Table 4

Clinical outcomes of the trial.

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Items

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Primary outcomes

 Primary outcomes of improving efficacy

  Platelet aggregation rate (platelet aggregation analyzer)

 Primary outcomes of reducing gastrointestinal side effects

  Change in calprotectin activity (ELISA) [17]

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Secondary outcomes

 Secondary outcomes of improving efficacy

  (1) Change in PAC-1 activity (flow cytometry)

  (2) Change in P-selectin activity (flow cytometry)

  (3) Change in P2Y12 acceptor activity (flow cytometry)

 Secondary outcomes of reducing gastrointestinal side effects

  (1) Change in I-FABP activity (ELISA) [18]

  (2) Change in fecal occult blood

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Safety outcomes

 (1) Serum biochemistry

 (2) Blood routine

 (3) Urine routine

 (4) Stool routine

 (5) ECG

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