Research Article

Resveratrol Alleviates Vascular Endothelial Damage Caused by Lower-Extremity Ischemia Reperfusion (I/R) through Regulating Keap1/Nrf2 Signaling-Mediated Oxidative Stress

Figure 4

The protective effect of RSV against oxidative stress in HUVECs induced by HR was abolished by knocking down Nrf2. (a) The ROS level in HUVECs treated with different strategies was measured by DCFH-DA assay. (b) The concentration of MDA and SOD was determined by commercial kits. (c) The expression of Nrf2, Keap1, and HO-1 was evaluated by Western blot ( vs. control, vs. HR, vs. HR, and vs. RSV + HR).
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