Tyrosinase Inhibitors from the Stems of Streblus Ilicifolius

Table 2

Docking results of 1 and 2 with oxy-tyrosinase.

Compound	oxy-tyrosinase (1 WX2)
	S values	Interactions	Targeting residues	Distance (Å)
1	–6.56	H-donor	PER404	1.85
		H-acceptor	ASN188	2.44
		π-π	HIS194	4.19
		π-σ	TRP184	5.15
				5.06
				5.47
		σ-σ	VAL195	4.09
2	–6.17	H-donor	ASP45	1.71
			ALA202	2.54
			MET201	2.97
		π-π	TRP184	4.98
		π-σ	ILE42	4.66
				4.61
		σ-σ	VAL195	4.73
Kojic acid^a	–4.50	H-donor	THR203	2.04
		Metal-acceptor	CU401	2.92
		π-π	HIS194	4.30

^aPositive control.