A Study on Gentiana dahurica Fisch Ethanol Extract Alleviating Alcoholic Liver Disease in Mice: A Metabolomic Analysis of the Liver
Table 1
Information on some differential metabolites.
Number
Metabolites
Content change
Classification
KEGG pathways
Control vs Alcohol
Alcohol vs Alcohol + GDEE
(KEGG brite)
1
Uridine 5′-diphosphate (UDP)
Up
Unchanged
Nucleic acids
(1); (2); (4)
2
Adenosine monophosphate (AMP)
Up
Unchanged
Nucleic acids
(1); (3); (4); (5); (6); (10)
3
Cytidine 5′-monophosphate (CMP)
Up
Unchanged
Nucleic acids
(1); (2)
4
Uracil
Down
Unchanged
Nucleic acids
(1); (2); (11)
5
Thymidine
Down
Unchanged
Nucleic acids
(1); (2)
6
Deoxyguanosine 5′-monophosphate (dGMP)
Up
Unchanged
Nucleic acids
(1); (3)
7
Deoxyuridine monophosphate (dUMP)
Down
Unchanged
Nucleic acids
(1); (2); (5)
8
2′-Deoxyuridine
Unchanged
Down
Nucleic acids
(1); (2); (7)
9
Adenosine 3′,5′-cyclic phosphate (cAMP)
Unchanged
Up
Nucleic acids
(1); (3); (6); (8); (9)
10
Adenylosuccinic acid
Unchanged
Up
Nucleic acids
(1); (3); (4); (12)
11
L-Alanine
Down
Unchanged
Amino acids
(1); (7); (12); (13); (14); (15)
12
L-Valine
Up
Unchanged
Amino acids
(1); (4); (11); (13); (14); (16)
13
Argininosuccinic acid
Up
Unchanged
Amino acids
(1); (12); (13)
14
Glucose 6-phosphate
Up
Unchanged
—
(1); (9); (15)
15
D-Xylose
Up
Down
Monosaccharides
(1); (7); (17); (18)
16
Glucosamine
Down
Unchanged
Monosaccharides
(1); (18)
17
(R)-Mevalonic acid 5-phosphate
Up
Down
—
(1); (19)
Note: the meaning of the numbers in column “KEGG pathways.” (1) metabolic pathways; (2) pyrimidine metabolism; (3) purine metabolism; (4) biosynthesis of cofactors; (5) antifolate resistance; (6) regulation of lipolysis in adipocytes; (7) ABC transporters; (8) insulin signaling pathway; (9) insulin secretion; (10) aldosterone synthesis and secretion; (11) pantothenate and CoA biosynthesis; (12) alanine, aspartate, and glutamate metabolism; (13) biosynthesis of amino acids; (14) protein digestion and absorption; (15) central carbon metabolism in cancer; (16) valine, leucine, and isoleucine degradation; (17) pentose and glucuronate interconversions; (18) amino sugar and nucleotide sugar metabolism; and (19) terpenoid backbone biosynthesis.
