Evodiamine Inhibits Gastric Cancer Cell Proliferation via PTEN-Mediated EGF/PI3K Signaling Pathway

Figure 7

Effect of evodiamine on the protein expression level of PTEN-mediated EGF/PI3K signaling pathways. (a) Western blot images of PTEN-mediated EGF/PI3K signaling pathways. (b) Relative PTEN protein level in AGS and BGC-823 cells. (c) Relative EGF protein level in AGS and BGC-823 cells. (d) Relative EGFR protein level in AGS and BGC-823 cells. (e) Relative PI3K protein level in AGS and BGC-823 cells. (f) Relative p-PI3K protein level in AGS and BGC-823 cells. (g) Relative AKT protein level in AGS and BGC-823 cells. (h) Relative p-AKT protein level in AGS and BGC-823 cells. (i) Relative mTOR protein level in AGS and BGC-823 cells. (j) Relative Beclin-1 protein level in AGS and BGC-823 cells. (k) Relative Bcl-2 protein level in AGS and BGC-823 cells. (l) Relative Bax protein level in AGS and BGC-823 cells. (m) Relative caspase-3 protein level in AGS and BGC-823 cells. (n) Relative caspase-8 protein level in AGS and BGC-823 cells. , ^∗∗ versus control group (0 μM). Data were analyzed using one-way ANOVA followed by LSD. All data are presented as the mean ± SD (n = 3).

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