Astragali Radix Contributes to the Inhibition of Liver Fibrosis via High-Mobility Group Box 1-Mediated Inflammatory Signaling Pathway

Figure 6

Effect of RA on type 1 collagen level and HMGB1/RAGE/c-Jun pathway in liver fibrosis induced by CCl₄. (a–e) Immunohistochemistry analysis for the effect of AR on type 1 collagen expression (original magnification, ×200; n = 3; (a): control group; (b): model group; (c): 2.7 g/kg AR group; (d) 5.4 g/kg AR group; (e) 10.8 g/kg AR group.) (f) The mean integrated optical density of COL-I. (g) Western blot images of RAGE, MEK1/2, p-MEK1/2, ERK1/2, p-ERK1/2, and p-cJun. (h) RAGE protein level. (i) p-MEK1/2 protein level. (j) p-ERK1/2 protein level. (k) p-cJun protein level.

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